Stability properties of neuronal microtubules

Peter W. Baas; Anand N. Rao; Andrew J. Matamoros; Lanfranco Leo

doi:10.1002/cm.21286

journal article Sep 01, 2016

Stability properties of neuronal microtubules

Peter W. Baas Anand N. Rao Andrew J. Matamoros Lanfranco Leo

Cytoskeleton Vol. 73 No. 9 pp. 442-460 · Wiley

View at Publisher Save 10.1002/cm.21286

Abstract

Neurons are terminally differentiated cells that use their microtubule arrays not for cell division but rather as architectural elements required for the elaboration of elongated axons and dendrites. In addition to acting as compression‐bearing struts that provide for the shape of the neuron, microtubules also act as directional railways for organelle transport. The stability properties of neuronal microtubules are commonly discussed in the biomedical literature as crucial to the development and maintenance of the nervous system, and have recently gained attention as central to the etiology of neurodegenerative diseases. Drugs that affect microtubule stability are currently under investigation as potential therapies for disease and injury of the nervous system. There is often a lack of consistency, however, in how the issue of microtubule stability is discussed in the literature, and this can affect the design and interpretation of experiments as well as potential therapeutic regimens. Neuronal microtubules are considered to be more stable than microtubules in dividing cells. On average, this is true, but in addition to an abundant stable microtubule fraction in neurons, there is also an abundant labile microtubule fraction. Both are functionally important. Individual microtubules consist of domains that differ in their stability properties, and these domains can also differ markedly in their composition as well as how they interact with various microtubule‐related proteins in the neuron. Myriad proteins and pathways have been discussed as potential contributors to microtubule stability in neurons. © 2016 Wiley Periodicals, Inc.

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Details

Published: Sep 01, 2016
Vol/Issue: 73(9)
Pages: 442-460
License: View

Authors

P

Peter W. Baas

Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania USA

A

Anand N. Rao

Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania USA

A

Andrew J. Matamoros

Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania USA

L

Lanfranco Leo

Department of Neurobiology and Anatomy Drexel University College of Medicine Philadelphia Pennsylvania USA

Funding

Craig H. Neilsen Foundation Award: 259350

Cite This Article

Peter W. Baas, Anand N. Rao, Andrew J. Matamoros, et al. (2016). Stability properties of neuronal microtubules. Cytoskeleton, 73(9), 442-460. https://doi.org/10.1002/cm.21286

Stability properties of neuronal microtubules

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