PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue

Conghe Tian; Kevin Burgess

doi:10.1002/cmdc.202000683

journal article Oct 28, 2020

PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue

Conghe Tian

Kevin Burgess

ChemMedChem Vol. 16 No. 2 pp. 316-318 · Wiley

View at Publisher Save 10.1002/cmdc.202000683

Abstract

AbstractPROteolysis TArgeting Chimeras (PROTACs) are emerging as critical tools in biomedicinal chemistry and drug design, but they have limitations. These limitations include a lack of guiding principles when selecting suitable E3 ligases to induce ubiquitinylation, and problems degrading cell‐surface receptors. This Highlight outlines some recent advances that circumvent some of these limitations, and new alternative methods to induce selective protein degradation.

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Cited By

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PROTACs: A novel strategy for cancer drug discovery and development

Xin Han, Yi Sun · 2023

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Metrics

12

Citations

7

References

Details

Published: Oct 28, 2020
Vol/Issue: 16(2)
Pages: 316-318
License: View

Authors

C

Conghe Tian

Department of Chemistry Texas A&M University Box 39912, College Station TX 77842 USA

K

Kevin Burgess

Department of Chemistry Texas A&M University Box 39912, College Station TX 77842 USA

Funding

National Science Foundation Award: CHE1608009

Welch Foundation

Cancer Prevention and Research Institute of Texas Award: RP170144

Cite This Article

Conghe Tian, Kevin Burgess (2020). PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue. ChemMedChem, 16(2), 316-318. https://doi.org/10.1002/cmdc.202000683

PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue

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