Amyloid‐β Inspired Short Peptide Amphiphile Facilitates Synthesis of Silver Nanoparticles as Potential Antibacterial Agents

Satyendra K. Tripathi; Khushboo Kesharwani; Grace Kaul; Abdul Akhir; Deepanshi Saxena; Ramesh Singh; Narendra K. Mishra; Archna Pandey; Sidharth Chopra; Khashti B. Joshi

doi:10.1002/cmdc.202200251

journal article Jun 28, 2022

Amyloid‐β Inspired Short Peptide Amphiphile Facilitates Synthesis of Silver Nanoparticles as Potential Antibacterial Agents

Satyendra K. Tripathi Khushboo Kesharwani Grace Kaul Abdul Akhir Deepanshi Saxena Ramesh Singh

Narendra K. Mishra

Archna Pandey Sidharth Chopra

Khashti B. Joshi

ChemMedChem Vol. 17 No. 15 · Wiley

View at Publisher Save 10.1002/cmdc.202200251

Abstract

AbstractAn amyloid‐β inspired biocompatible short peptide amphiphile (sPA) molecule was used for controlled and targeted delivery of bioactive silver nanoparticles via transforming sPA nanostructures. Such sPA‐AgNPs hybrid structures can be further used to develop antibacterial materials to combat emerging bacterial resistance. Due to the excellent antibacterial activity of silver, the growth of clinically relevant bacteria was inhibited in the presence of AgNPs‐sPA hybrids. Bacterial tests demonstrated that the high biocompatibility and low cytotoxicity of the designed sPA allow it to work as a model drug delivery agent. It therefore shows great potential in locally addressing bacterial infections. The results of our study suggest that these nanodevices have the potential to trap and then engage in the facile delivery of their chemical payload at the target site, thereby working as potential delivery materials. This system has potential therapeutic value for the treatment of microbiota triggered progression of neurodegenerative diseases.

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Published: Jun 28, 2022
Vol/Issue: 17(15)
License: View

Authors

S

Satyendra K. Tripathi

Department of Chemistry School of Chemical Science and Technology Dr.Harisingh Gour Vishwavidyalaya (A Central University) Sagar MP 470003 India

K

Khushboo Kesharwani

Department of Chemistry School of Chemical Science and Technology Dr.Harisingh Gour Vishwavidyalaya (A Central University) Sagar MP 470003 India

G

Grace Kaul

Department of Microbiology CSIR-Central Drug Research Institute Sitapur Road, Janakipuram Extension Lucknow India; Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India

A

Abdul Akhir

Department of Microbiology CSIR-Central Drug Research Institute Sitapur Road, Janakipuram Extension Lucknow India

D

Deepanshi Saxena

Department of Microbiology CSIR-Central Drug Research Institute Sitapur Road, Janakipuram Extension Lucknow India

R

Ramesh Singh

Department of Chemistry School of Chemical Science and Technology Dr.Harisingh Gour Vishwavidyalaya (A Central University) Sagar MP 470003 India

N

Narendra K. Mishra

Department of Chemistry University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark

A

Archna Pandey

Department of Chemistry School of Chemical Science and Technology Dr.Harisingh Gour Vishwavidyalaya (A Central University) Sagar MP 470003 India

S

Sidharth Chopra

Department of Microbiology CSIR-Central Drug Research Institute Sitapur Road, Janakipuram Extension Lucknow India; Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002 India

K

Khashti B. Joshi

Department of Chemistry School of Chemical Science and Technology Dr.Harisingh Gour Vishwavidyalaya (A Central University) Sagar MP 470003 India

Cite This Article

Satyendra K. Tripathi, Khushboo Kesharwani, Grace Kaul, et al. (2022). Amyloid‐β Inspired Short Peptide Amphiphile Facilitates Synthesis of Silver Nanoparticles as Potential Antibacterial Agents. ChemMedChem, 17(15). https://doi.org/10.1002/cmdc.202200251

Amyloid‐β Inspired Short Peptide Amphiphile Facilitates Synthesis of Silver Nanoparticles as Potential Antibacterial Agents

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