Autophagy‐Mediated Targeted Protein Degradation

Jinning Shao; Shangzhi Xie; Shurui Hong; Linghui Qian

doi:10.1002/cmdc.202400866

journal article Dec 26, 2024

Autophagy‐Mediated Targeted Protein Degradation

Jinning Shao Shangzhi Xie Shurui Hong Linghui Qian

ChemMedChem Vol. 20 No. 6 · Wiley

View at Publisher Save 10.1002/cmdc.202400866

Abstract

AbstractAutophagy is an evolutionarily conserved turnover process in eukaryotes, mediating the delivery of various cellular components to lysosomes for degradation and facilitating the recycling of the breakdown products to maintain homeostasis. By harnessing this powerful autophagy‐lysosomal degradation system, strategies for targeted protein degradation (TPD) have been emerging to remove specific disease‐related proteins (both intracellular and cell‐surface proteins) for complete elimination of their functions, bringing new insights to drug discovery. Herein, we give a brief introduction on how autophagy works followed by a focus on available small‐molecule and macromolecule‐based strategies for TPD mediated by autophagy.

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Metrics

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Citations

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References

Details

Published: Dec 26, 2024
Vol/Issue: 20(6)
License: View

Authors

J

Jinning Shao

Institute of Drug Metabolism and Pharmaceutical Analysis Research Center for Clinical Pharmacy College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

S

Shangzhi Xie

Institute of Drug Metabolism and Pharmaceutical Analysis Research Center for Clinical Pharmacy College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

S

Shurui Hong

Institute of Drug Metabolism and Pharmaceutical Analysis Research Center for Clinical Pharmacy College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

L

Linghui Qian

Institute of Drug Metabolism and Pharmaceutical Analysis Research Center for Clinical Pharmacy College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University Yantai 264005 China

Funding

National Natural Science Foundation of China Award: 82473881, 82273887

Cite This Article

Jinning Shao, Shangzhi Xie, Shurui Hong, et al. (2024). Autophagy‐Mediated Targeted Protein Degradation. ChemMedChem, 20(6). https://doi.org/10.1002/cmdc.202400866

Autophagy‐Mediated Targeted Protein Degradation

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