Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: Anatomical evidence for cholinergic modulation of glutamatergic prefronto‐striatal pathways

Adriana A. Alcantara; Ladislav Mrzljak; Robert L. Jakab; Allan I. Levey; Steven M. Hersch; Patricia S. Goldman‐Rakic

doi:10.1002/cne.1186

journal article May 01, 2001

Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: Anatomical evidence for cholinergic modulation of glutamatergic prefronto‐striatal pathways

Adriana A. Alcantara Ladislav Mrzljak Robert L. Jakab Allan I. Levey

Steven M. Hersch Patricia S. Goldman‐Rakic

Journal of Comparative Neurology Vol. 434 No. 4 pp. 445-460 · Wiley

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Abstract

AbstractThe cellular and subcellular localization of muscarinic receptor proteins m1 and m2 was examined in the neostriatum of macaque monkeys by using light and electron microscopic immunocytochemical techniques. Double‐labeling immunocytochemistry revealed m1 receptors in calbindin‐D28k–positive medium spiny projection neurons. Muscarinic m1 labeling was dramatically more intense in the striatal matrix compartment in juvenile monkeys but more intense in striosomes in the adult caudate, suggesting that m1 expression undergoes a developmental age‐dependent change. Ultrastructurally, m1 receptors were predominantly localized in asymmetric synapse‐forming spines, indicating that these spines receive extrastriatal excitatory afferents. The association of m1‐positive spines with lesion‐induced degenerating prefronto‐striatal axon terminals demonstrated that these afferents originate in part from the prefrontal cortex. The synaptic localization of m1 in these spines indicates a role of m1 in the modulation of excitatory neurotransmission. To a lesser extent, m1 was present in symmetric synapses, where it may also modulate inhibitory neurotransmission originating from local striatal neurons or the substantia nigra. Conversely, m2/choline acetyltransferase (ChAT) double labeling revealed that m2‐positive neurons corresponded to large aspiny cholinergic interneurons and ultrastructurally, that the majority of m2 labeled axons formed symmetric synapses. The remarkable segregation of the m1 and m2 receptor proteins to projection and local circuit neurons suggests a functional segregation of m1 and m2 mediated cholinergic actions in the striatum: m1 receptors modulate extrinsic glutamatergic and monoaminergic afferents and intrinsic GABAergic afferents onto projection neurons, whereas m2 receptors regulate acetylcholine release from axons of cholinergic interneurons. J. Comp. Neurol. 434:445–460, 2001. © 2001 Wiley‐Liss, Inc.

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Details

Published: May 01, 2001
Vol/Issue: 434(4)
Pages: 445-460
License: View

Authors

Patricia S. Goldman‐Rakic

Cite This Article

Adriana A. Alcantara, Ladislav Mrzljak, Robert L. Jakab, et al. (2001). Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: Anatomical evidence for cholinergic modulation of glutamatergic prefronto‐striatal pathways. Journal of Comparative Neurology, 434(4), 445-460. https://doi.org/10.1002/cne.1186

Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: Anatomical evidence for cholinergic modulation of glutamatergic prefronto‐striatal pathways

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