Diurnal variation of c‐Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)

Skirmantas Janusonis; Katherine V. Fite

doi:10.1002/cne.1368

journal article Oct 22, 2001

Diurnal variation of c‐Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)

Skirmantas Janusonis

Katherine V. Fite

Journal of Comparative Neurology Vol. 440 No. 1 pp. 31-42 · Wiley

View at Publisher Save 10.1002/cne.1368

Abstract

AbstractRecent studies suggest that the dorsal raphe nucleus (DRN) of the brainstem contains several subdivisions that differ both anatomically and neurochemically. The present study examined whether variation of c‐Fos expression across the 24‐hour light‐dark cycle may also be different in these subdivisions. Animals were kept on a 12:12 light‐dark cycle, were perfused at seven different time points, and brain sections were processed by using c‐Fos immunocytochemistry. At all coronal levels of the DRN, c‐Fos expression reached a peak 1 hour after the light‐dark transition (lights‐off) and reached its lowest levels in the middle of the light period. In contrast to the light‐dark transition, c‐Fos levels did not change significantly after the dark‐light transition (lights‐on). One‐way analysis of variance (ANOVA) revealed that the diurnal variation of c‐Fos expression was highly significant in the caudal ventral DRN. Similar variation in c‐Fos expression also was observed in the other DRN subdivisions, but this variation appeared to gradually diminish in the caudal‐to‐rostral and ventromedial‐to‐dorsomedial directions. Double‐label immunocytochemistry revealed that, 1 hour after lights‐off, only 11% of c‐Fos‐positive neurons in the caudal ventral DRN were serotonin (5‐HT)‐immunoreactive. These results suggest that DRN subdivisions may differ functionally with regard to the diurnal cycle, and that these differences may be reflected in the activity of nonserotonergic cells in the DRN. J. Comp. Neurol. 440:31–42, 2001. © 2001 Wiley‐Liss, Inc.

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Details

Published: Oct 22, 2001
Vol/Issue: 440(1)
Pages: 31-42
License: View

Authors

Cite This Article

Skirmantas Janusonis, Katherine V. Fite (2001). Diurnal variation of c‐Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus). Journal of Comparative Neurology, 440(1), 31-42. https://doi.org/10.1002/cne.1368

Diurnal variation of c‐Fos expression in subdivisions of the dorsal raphe nucleus of the Mongolian gerbil (Meriones unguiculatus)

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