MicroRNA replacement therapy in cancer

Homa Mollaei; Reza Safaralizadeh; Zeinab Rostami

doi:10.1002/jcp.28058

journal article Jan 03, 2019

MicroRNA replacement therapy in cancer

Homa Mollaei Reza Safaralizadeh

Zeinab Rostami

Journal of Cellular Physiology Vol. 234 No. 8 pp. 12369-12384 · Wiley

View at Publisher Save 10.1002/jcp.28058

Abstract

AbstractDespite the recent progress in cancer management approaches, the mortality rate of cancer is still growing and there are lots of challenges in the clinics in terms of novel therapeutics. MicroRNAs (miRNA) are regulatory small noncoding RNAs and are already confirmed to have a great role in regulating gene expression level by targeting multiple molecules that affect cell physiology and disease development. Recently, miRNAs have been introduced as promising therapeutic targets for cancer treatment. Regulatory potential of tumor suppressor miRNAs, which enables regulation of entire signaling networks within the cells, makes them an interesting option for developing cancer therapeutics. In this regard, over recent decades, scientists have aimed at developing powerful and safe targeting approaches to restore these suppressive miRNAs in cancerous cells.The present review summarizes the function of miRNAs in tumor development and presents recent findings on how miRNAs have served as therapeutic agents against cancer, with a special focus on tumor suppressor miRNAs (mimics). Moreover, the latest investigations on the therapeutic strategies of miRNA delivery have been presented.

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Metrics

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References

Details

Published: Jan 03, 2019
Vol/Issue: 234(8)
Pages: 12369-12384
License: View

Authors

H

Homa Mollaei

Department of Biology, Faculty of Sciences University of Birjand Birjand Iran

R

Reza Safaralizadeh

Department of Animal Biology, Faculty of Natural Sciences University of Tabriz Tabriz Iran

Z

Zeinab Rostami

Department of Immunology Birjand University of Medical Sciences Birjand Iran

Cite This Article

Homa Mollaei, Reza Safaralizadeh, Zeinab Rostami (2019). MicroRNA replacement therapy in cancer. Journal of Cellular Physiology, 234(8), 12369-12384. https://doi.org/10.1002/jcp.28058

MicroRNA replacement therapy in cancer

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