Alterations of signaling pathways in muscle tissues of patients with amyotrophic lateral sclerosis

Fei Yin; Fei Ye; Limei Tan; Katherine Liu; Zhaopeng Xuan; Jinnan Zhang; Wenhu Wang; Yanli Zhang; Xinmei Jiang; David Y. Zhang

doi:10.1002/mus.23411

journal article Sep 19, 2012

Alterations of signaling pathways in muscle tissues of patients with amyotrophic lateral sclerosis

Fei Yin

Fei Ye

Limei Tan Katherine Liu Zhaopeng Xuan Jinnan Zhang Wenhu Wang

Yanli Zhang

Xinmei Jiang David Y. Zhang

Muscle & Nerve Vol. 46 No. 6 pp. 856-860 · Wiley

View at Publisher Save 10.1002/mus.23411

Abstract

AbstractIntroduction: Amyotrophic lateral sclerosis (ALS), a degenerative disorder of the central nervous system, manifests as progressive weakening of muscles. The diagnosis and prognosis of ALS are often unclear, so useful biomarkers are needed. Methods: Total proteins were extracted from muscle samples from 36 ALS, 17 spinal muscular atrophy (SMA), and 36 normal individuals. The expression levels of 134 proteins and phosphoproteins were assessed using protein pathway array analysis. Results: Seventeen proteins were differentially expressed between ALS and normal muscle, and 9 proteins were differentially expressed between ALS and SMA muscle. The low‐level expression of Akt and Factor XIIIB correlates with unfavorable survival, and the risk score calculated based on these proteins predicts the survival of each individual patient. Conclusions: Some proteins could be selected as clinically useful biomarkers. Specifically, Akt and Factor XIIIB were found to be promising biomarkers for estimating prognosis in ALS. Muscle Nerve, 2012

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References

Details

Published: Sep 19, 2012
Vol/Issue: 46(6)
Pages: 856-860
License: View

Authors

New York University 1 Department of Chemistry, , New York, New York 10003, USA

Cite This Article

Fei Yin, Fei Ye, Limei Tan, et al. (2012). Alterations of signaling pathways in muscle tissues of patients with amyotrophic lateral sclerosis. Muscle & Nerve, 46(6), 856-860. https://doi.org/10.1002/mus.23411

Alterations of signaling pathways in muscle tissues of patients with amyotrophic lateral sclerosis

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