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journal article Nov 20, 2002

Issues and concerns of couples presenting for preimplantation genetic diagnosis (PGD)

Mandy G. Katz Lara Fitzgerald Agnes Bankier Julian Savulescu ORCID David S. Cram ORCID
Prenatal Diagnosis Vol. 22 No. 12 pp. 1117-1122 · Wiley
View at Publisher Save 10.1002/pd.498
Abstract
AbstractBackgroundThe use of preimplantation genetic diagnosis (PGD) to select genetically ‘normal’ human embryos and to transfer them to the uterus of a woman has generated considerable controversy. Debate has occurred over the implications of PGD, sex selection, safety of embryonic manipulation and eugenics. This study evaluates a range of social and moral concerns of couples towards PGD and assisted reproductive technologies (ART) prior to treatment to obtain unbiased authentic attitudes independent of the treatment cycle and the outcome.MethodsA total of 121 subjects were administered a structured questionnaire after each couple's in vitro fertilization (IVF) or genetic counselling session. Group A consisted of 41 subjects presenting for PGD of single gene disorders (PGD‐SG) and group B consisted of 48 subjects undertaking PGD for aneuploidy screening (PGD‐AS). A control group consisted of 32 subjects that were about to commence their first IVF cycle.Results and discussionAll groups found PGD to be a highly acceptable treatment. They expressed little concern about its extension to testing non‐disease states such as sex and they were strongly in favour of a shared decision‐making model in which couples have considerable autonomy over decisions about the embryo(s) to transfer. Differences between the groups included issues surrounding the transfer of embryos, restrictions to PGD and the destruction of embryos. Copyright © 2002 John Wiley & Sons, Ltd.
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References
42
[13]
Holm S (1998)
[17]
Lavery SA "Patients perspectives of PGD and its psychological impact" Hum Reprod (2000)
Cited By
58
A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions

Tara Hughes, Timothy Bracewell-Milnes · 2021

Human Reproduction Update
Metrics
58
Citations
42
References
Details
Published
Nov 20, 2002
Vol/Issue
22(12)
Pages
1117-1122
License
View
Authors
M
Mandy G. Katz
L
Lara Fitzgerald

From the Centre for Clinical Genetics, Sydney Children’s Hospital (E.P.K., K.B., S.R., S.K.), NSW Health Pathology Randwick Genomics Laboratory (E.P.K., B.R., C.C.C., F.Z., J.F., M.B., N.Q., S.R., S.K., T.R., Y.Z.), the School of Clinical Medicine (E.P.K., M.B.), the School of Women’s and Children’s Health (L. Freeman, S.R., S.K.), and the Randwick Clinical Campus, Neuroscience Research Australia (Y.Z.), University of New South Wales, Randwick, Victorian Clinical Genetics Services (M.B.D., A.D.A., A.K.-P., C.H., C.L., I.D., J.E.M., K.S., L.G., L.T., M.C.O., M. Wall, M.T.M.C., M.M.F., N.L., S. Lunke, S. Eggers), the Bruce Lefroy Centre, Murdoch Children’s Research Institute (M.B.D., E.A.K.), the Department of Paediatrics (M.B.D., A.D.A., E.T., J.L.H., S. Lewis, B.J.M., J. Massie, E.A.K., Z.F.), the Department of General Practice and Centre for Cancer Research (J.D.E.), and the Department of Pathology (Sebastian Lunke), University of Melbourne, Murdoch Children’s Research Institute (A.D.A., E.T., J.C., J.L.H...

A
Agnes Bankier
J
Julian Savulescu
D
David S. Cram
Cite This Article
Mandy G. Katz, Lara Fitzgerald, Agnes Bankier, et al. (2002). Issues and concerns of couples presenting for preimplantation genetic diagnosis (PGD). Prenatal Diagnosis, 22(12), 1117-1122. https://doi.org/10.1002/pd.498
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