Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

Linda C. Noukeu; Joseph Wolf; Baohong Yuan; SUBHASH BANERJEE; Kytai T. Nguyen

doi:10.1002/smll.201800644

journal article Jun 27, 2018

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

Linda C. Noukeu Joseph Wolf

Baohong Yuan SUBHASH BANERJEE Kytai T. Nguyen

Small Vol. 14 No. 32 · Wiley

View at Publisher Save 10.1002/smll.201800644

Abstract

AbstractPeripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional capacity. Although the PAD occurrence rate is increasing in the elderly population, outcomes with current treatment strategies are suboptimal. Hence, there is an urgent need to develop new technologies that overcome limitations of traditional modalities for PAD detection and therapy. In this Review, the application of nanotechnology as a tool that bridges the gap in PAD diagnosis and therapy is in focus. Several materials including synthetic, natural, biodegradable, and biocompatible materials are used to develop nanoparticles for PAD diagnostic and/or therapeutic applications. Moreover, various recent research approaches are being explored to diagnose PAD through multimodality imaging with different nanoplatforms. Further efforts include targeted delivery of various therapeutic agents using nanostructures as carriers to treat PAD. Last, but not least, despite being a fairly new field, researchers are exploring the use of nanotheranostics for PAD detection and therapy.

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Details

Published: Jun 27, 2018
Vol/Issue: 14(32)
License: View

Authors

L

Linda C. Noukeu

Department of Bioengineering University of Texas at Arlington Arlington TX 76010 USA; Joint Biomedical Engineering Program University of Texas Southwestern Dallas TX 75235 USA

J

Joseph Wolf

Department of Bioengineering University of Texas at Arlington Arlington TX 76010 USA; Joint Biomedical Engineering Program University of Texas Southwestern Dallas TX 75235 USA

B

Baohong Yuan

Department of Bioengineering University of Texas at Arlington Arlington TX 76010 USA; Joint Biomedical Engineering Program University of Texas Southwestern Dallas TX 75235 USA

S

SUBHASH BANERJEE

Division of Cardiology University of Texas Southwestern Medical Center Dallas TX 75235 USA

K

Kytai T. Nguyen

Department of Bioengineering University of Texas at Arlington Arlington TX 76010 USA; Joint Biomedical Engineering Program University of Texas Southwestern Dallas TX 75235 USA

Funding

National Heart, Lung, and Blood Institute Award: R01 HL118498

Cite This Article

Linda C. Noukeu, Joseph Wolf, Baohong Yuan, et al. (2018). Nanoparticles for Detection and Treatment of Peripheral Arterial Disease. Small, 14(32). https://doi.org/10.1002/smll.201800644

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

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