Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity

Shihao Zhang; Lei Huang; Mengxuan Bian; Lan Xiao; Dong Zhou; Ziwei Tao; Zheng Zhao; Jian Zhang; Li‐Bo Jiang; Yulin Li

doi:10.1002/smll.202405311

journal article Aug 15, 2024

Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity

Shihao Zhang

Lei Huang

Mengxuan Bian Lan Xiao

Dong Zhou

Ziwei Tao Zheng Zhao

Jian Zhang

Li‐Bo Jiang Yulin Li

Small Vol. 20 No. 47 · Wiley

View at Publisher Save 10.1002/smll.202405311

Abstract

Abstract

The use of membrane‐based guided bone regeneration techniques has great potential for single‐stage reconstruction of critical‐sized bone defects. Here, a multifunctional bone regeneration membrane combining flexible elasticity, electrical stimulation (ES) and osteoinductive activity is developed by in situ doping of MXene 2D nanomaterials with conductive functionality and
β
‐TCP particles into a Poly(lactic acid‐carbonate (PDT) composite nano‐absorbable membrane (P/T/MXene) via electrostatic spinning technique. The composite membrane has good feasibility due to its temperature sensitivity, elastic memory capacity, coordinated degradation profile and easy preparation process. In vitro experiments showed the P/T/MXene membrane effectively promoted the recruitment and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) under ES and enhanced the angiogenic capacity of endothelial cells, which synergistically promoted bone regeneration through neovascularization. In addition, an in vivo rat model of cranial bone defects further confirmed the bone regeneration efficacy of the P/T/MXene membrane. In conclusion, the developed P/T/MXene membrane can effectively promote bone regeneration through their synergistic multifunctional effects, suggesting the membranes have great potential for guiding tissue regeneration and providing guidance for the biomaterials design.

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Citations

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References

Details

Published: Aug 15, 2024
Vol/Issue: 20(47)
License: View

Authors

S

Shihao Zhang

The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

L

Lei Huang

Department of Orthopedic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

M

Mengxuan Bian

Department of Orthopedic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

L

Lan Xiao

School of Medicine and Dentistry Griffith University Australia 4222 Australia

D

Dong Zhou

The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

Z

Ziwei Tao

The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

Z

Zheng Zhao

The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

J

Jian Zhang

Department of Orthopedic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

L

Li‐Bo Jiang

Department of Orthopedic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Y

Yulin Li

The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

Funding

National Natural Science Foundation of China Award: 51973060

National Key Research and Development Program of China Award: 2022YFC2405802

Cite This Article

Shihao Zhang, Lei Huang, Mengxuan Bian, et al. (2024). Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity. Small, 20(47). https://doi.org/10.1002/smll.202405311

Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity

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