Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study

M. Valenzise; B. Bombaci; F. Lombardo; S. Passanisi; C. Lombardo; C. Lugarà; F. D’Amico; L. Grasso; M. Aguennouz; A. Catalano; G. Salzano

doi:10.1007/s40618-024-02414-2

journal article Jul 04, 2024

Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study

M. Valenzise B. Bombaci

F. Lombardo S. Passanisi C. Lombardo C. Lugarà F. D’Amico L. Grasso M. Aguennouz A. Catalano

G. Salzano

Journal of Endocrinological Investigation Vol. 48 No. 1 pp. 227-232 · Springer Science and Business Media LLC

View at Publisher Save 10.1007/s40618-024-02414-2

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References

30

[1]

Type 1 diabetes

Mark A Atkinson, George S Eisenbarth, Aaron W Michels

The Lancet 2014 10.1016/s0140-6736(13)60591-7

[2]

Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ (2010) Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 39(3):481–497 10.1016/j.ecl.2010.05.011

[3]

Passanisi S, Salzano G, Bombaci B, Lombardo F (2021) Clinical and genetic features of maturity-onset diabetes of the young in pediatric patients: a 12-year monocentric experience. Diabetol Metab Syndr 13(1):96 10.1186/s13098-021-00716-6

[4]

Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study

Gabriel A Gregory, Thomas I G Robinson, Sarah E Linklater et al.

The Lancet Diabetes & Endocrinology 2022 10.1016/s2213-8587(22)00218-2

[5]

Prentice A, Schoenmakers I, Laskey MA, de Bono S, Ginty F, Goldberg GR (2006) Nutrition and bone growth and development. Proc Nutr Soc 65(4):348–360 10.1079/pns2006519

[6]

The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations

C. M. Weaver, C. M. Gordon, K. F. Janz et al.

Osteoporosis International 2016 10.1007/s00198-015-3440-3

[7]

Madsen JOB, Jørgensen NR, Pociot F, Johannesen J (2019) Bone turnover markers in children and adolescents with type 1 diabetes—A systematic review. Pediatr Diabetes 20(5):510–522

[8]

Karsenty G (2023) Osteocalcin: A Multifaceted Bone-Derived Hormone. Annu Rev Nutr 43:55–71 10.1146/annurev-nutr-061121-091348

[9]

Komori T (2020) Functions of osteocalcin in bone, pancreas, testis, and muscle. Int J Mol Sci 21(20):7513 10.3390/ijms21207513

[10]

Kuo TR, Chen CH (2017) Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives. Biomark Res 5:18 10.1186/s40364-017-0097-4

[11]

Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C et al (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130(3):456–469 10.1016/j.cell.2007.05.047

[12]

Sabek OM, Nishimoto SK, Fraga D, Tejpal N, Ricordi C, Gaber AO (2015) Osteocalcin effect on human β-Cells mass and function. Endocrinology 156(9):3137–3146 10.1210/en.2015-1143

[13]

Madsen JOB, Herskin CW, Zerahn B, Jørgensen NR, Olsen BS, Pociot F et al (2020) reased markers of bone turnover in children and adolescents with type 1 diabetes. Pediatr Diabetes 21(3):505–514 10.1111/pedi.12987

[14]

2. Classification and Diagnosis of Diabetes:Standards of Care in Diabetes—2023

Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda et al.

Diabetes Care 2023 10.2337/dc23-s002

[15]

ISPAD Clinical Practice Consensus Guidelines 2022: Diabetic ketoacidosis and hyperglycemic hyperosmolar state

Nicole Glaser, Maria Fritsch, Leena Priyambada et al.

Pediatric Diabetes 2022 10.1111/pedi.13406

[16]

Zhao C, Liang J, Yang Y, Yu M, Qu X (2017) The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms. Front Endocrinol 8:98 10.3389/fendo.2017.00098

[17]

Otani T, Mizokami A, Hayashi Y, Gao J, Mori Y, Nakamura S et al (2015) Signaling pathway for adiponectin expression in adipocytes by osteocalcin. Cell Signal 27(3):532–544 10.1016/j.cellsig.2014.12.018

[18]

Ferron M, Lacombe J (2014) Regulation of energy metabolism by the skeleton: osteocalcin and beyond. Arch Biochem Biophys 561:137–146 10.1016/j.abb.2014.05.022

[19]

Obri A, Khrimian L, Karsenty G, Oury F (2018) Osteocalcin in the brain: from embryonic development to age-related decline in cognition. Nat Rev Endocrinol 14(3):174–182 10.1038/nrendo.2017.181

[20]

Du J, Zhang M, Lu J, Zhang X, Xiong Q, Xu Y et al (2016) Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK. Endocrine 53(3):701–709 10.1007/s12020-016-0926-5

[21]

Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N et al (2005) Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem 280(48):40201–40209 10.1074/jbc.m505186200

[22]

Pi M, Kapoor K, Ye R, Nishimoto SK, Smith JC, Baudry J et al (2016) Evidence for osteocalcin binding and activation of GPRC6A in β-Cells. Endocrinology 157(5):1866–1880 10.1210/en.2015-2010

[23]

Karalazou P, Ntelios D, Chatzopoulou F, Fragou A, Taousani M, Mouzaki K et al (2019) OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D. Ital J Pediatr 45(1):161 10.1186/s13052-019-0748-1

[24]

Palui R, Pramanik S, Mondal S, Ray S (2021) Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus. World J Diabetes 12(6):706–729 10.4239/wjd.v12.i6.706

[25]

Yoshida K, Urakami T, Morioka I (2021) Glucagon stimulation test as a possible predictor of residual β-cell function. Pediatr Int 63(5):536–542 10.1111/ped.14462

[26]

Sabek OM, Redondo MJ, Nguyen DT, Beamish CA, Fraga DW, Hampe CS et al (2020) Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes. Endocrinol Diabetes Metab 3(1):e00104 10.1002/edm2.104

[27]

Redondo MJ, Shirkey BA, Fraga DW, Gaber AO, Sabek OM (2017) Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes. Pediatr Diabetes 18(8):869–873 10.1111/pedi.12501

[28]

Jamiołkowska-Sztabkowska M, Głowińska-Olszewska B, Bossowski A (2021) C-peptide and residual β-cell function in pediatric diabetes - state of the art. Pediatr Endocrinol Diabetes Metab 27(2):123–133 10.5114/pedm.2021.107165

[29]

Massry SG, Kurokawa K, Arieff AI, Ben-Isaac C (1974) Editorial: Metabolic acidosis of hyperparathyroidism. Arch Intern Med 134(2):385–387 10.1001/archinte.1974.00320200195032

[30]

Oh SB, Lee WY, Nam HK, Rhie YJ, Lee KH (2019) Serum osteocalcin levels in overweight children. Ann Pediatr Endocrinol Metab 24(2):104–107 10.6065/apem.2019.24.2.104

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Details

Published: Jul 04, 2024
Vol/Issue: 48(1)
Pages: 227-232
License: View

Authors

DEI/ARCES University of Bologna Viale del Risorgimento 2 40136 Bologna Italy

Allergy Unit Verona University Hospital Verona Italy

Department of Endocrinology and Metabolism, University of Pisa, 56100 Pisa, Italy

Cite This Article

M. Valenzise, B. Bombaci, F. Lombardo, et al. (2024). Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study. Journal of Endocrinological Investigation, 48(1), 227-232. https://doi.org/10.1007/s40618-024-02414-2

Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study

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