Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

Silvia Affὸ; Laura Sererols-Viñas; Gemma Garcia-Vicién; Massimiliano Cadamuro; Sanjukta Chakraborty; Alphonse E. Sirica

doi:10.1016/j.ajpath.2024.07.009

journal article Open Access Mar 01, 2025

Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

Silvia Affὸ Laura Sererols-Viñas Gemma Garcia-Vicién Massimiliano Cadamuro

Sanjukta Chakraborty

Alphonse E. Sirica

The American Journal of Pathology Vol. 195 No. 3 pp. 378-396 · Elsevier BV

View at Publisher Save 10.1016/j.ajpath.2024.07.009

Topics

No keywords indexed for this article. Browse by subject →

References

201

[1]

Kendall "Anatomical, histomorphological and molecular classification of cholangiocarcinoma" Liver Int (2019) 10.1111/liv.14093

[2]

Sirica "Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression" Adv Cancer Res (2021) 10.1016/bs.acr.2020.10.005

[3]

Vijgen "Pathology of intrahepatic cholangiocarcinoma" Hepatobiliary Surg Nutr (2017) 10.21037/hbsn.2016.11.04

[4]

Sirica "Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting" Hepatology (2014) 10.1002/hep.26762

[5]

Brindley "Cholangiocarcinoma" Nat Rev Dis Primers (2021) 10.1038/s41572-021-00300-2

[6]

Sirica "Intrahepatic cholangiocarcinoma: continuing challenges and translational advances" Hepatology (2019) 10.1002/hep.30289

[7]

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Min Zhang, Hui Yang, Lingfei Wan et al.

Journal of Hepatology 2020 10.1016/j.jhep.2020.05.039

[8]

Affò "Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations" Cancer Cell (2021) 10.1016/j.ccell.2021.03.012

[9]

Sirica "The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma" Nat Rev Gastroenterol Hepatol (2011) 10.1038/nrgastro.2011.222

[10]

Kajiyama "The significance of stromal desmoplasia in intrahepatic cholangiocarcinoma: a special reference of 'scirrhous-type' and 'nonscirrhous-type' growth" Am J Surg Pathol (1999) 10.1097/00000478-199908000-00006

[11]

Tothill "Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome" Clin Cancer Res (2008) 10.1158/1078-0432.ccr-08-0196

[12]

DeClerck "Desmoplasia: a response or a niche?" Cancer Discov (2012) 10.1158/2159-8290.cd-12-0348

[13]

Whatcott "Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer" Clin Cancer Res (2015) 10.1158/1078-0432.ccr-14-1051

[14]

Kojima "Prognostic impact of desmoplastic reaction evaluation for intrahepatic cholangiocarcinoma" Anticancer Res (2020) 10.21873/anticanres.14476

[15]

Guedj "Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma" Mod Pathol (2021) 10.1038/s41379-020-00656-y

[16]

Mertens "Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma" Cancer Res (2013) 10.1158/0008-5472.can-12-2130

[17]

Jiang "Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix" J Clin Invest (2020) 10.1172/jci136760

[18]

Montori "Cancer-associated fibroblasts in cholangiocarcinoma: current knowledge and possible implications for therapy" J Clin Med (2022) 10.3390/jcm11216498

[19]

Cholangiocarcinoma — novel biological insights and therapeutic strategies

Sumera I. Ilyas, Silvia Affo, Lipika Goyal et al.

Nature Reviews Clinical Oncology 2023 10.1038/s41571-023-00770-1

[20]

Luo "Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment" Nat Commun (2022) 10.1038/s41467-022-34395-2

[21]

Martin-Serrano "Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications" Gut (2023) 10.1136/gutjnl-2021-326514

[22]

Augsten "Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment" Front Oncol (2014) 10.3389/fonc.2014.00062

[23]

Chen "Clinical and therapeutic relevance of cancer-associated fibroblasts" Nat Rev Clin Oncol (2021) 10.1038/s41571-021-00546-5

[24]

Fabris "The tumor microenvironment in cholangiocarcinoma progression" Hepatology (2021) 10.1002/hep.31410

[25]

Cantallops Vilà "Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma" Hepatology (2024) 10.1097/hep.0000000000000206

[26]

Banales "Cholangiocarcinoma 2020: the next horizon in mechanisms and management" Nat Rev Gastroenterol Hepatol (2020) 10.1038/s41575-020-0310-z

[27]

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

Cédric Zeltz, Irina Primac, Pugazendhi Erusappan et al.

Seminars in Cancer Biology 2020 10.1016/j.semcancer.2019.08.004

[28]

Ravichandra "Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance" Adv Cancer Res (2022) 10.1016/bs.acr.2022.01.009

[29]

Ying "Cancer-associated fibroblasts in hepatocellular carcinoma and cholangiocarcinoma" Cell Mol Gastroenterol Hepatol (2023) 10.1016/j.jcmgh.2023.01.006

[30]

Goncalves-Ribeiro "Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells" Oncotarget (2016) 10.18632/oncotarget.11121

[31]

Brivio "Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness" World J Hepatol (2017) 10.4254/wjh.v9.i9.455

[32]

Sirica "Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma" Curr Opin Gastroenterol (2011) 10.1097/mog.0b013e32834405c3

[33]

Sirica "A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines" Hepatology (2008) 10.1002/hep.22088

[34]

Manzanares "Overexpression of periostin and distinct mesothelin forms predict malignant progression in a rat cholangiocarcinoma model" Hepatol Commun (2018) 10.1002/hep4.1131

[35]

Berdiel-Acer "Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information" Mol Oncol (2014) 10.1016/j.molonc.2014.04.006

[36]

Su "CD10(+)GPR77(+) cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness" Cell (2018) 10.1016/j.cell.2018.01.009

[37]

Zhang "Tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer" Cancer Cell (2020) 10.1016/j.ccell.2020.06.005

[38]

Francescone "Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast-driven nutritional support and immunosuppression" Cancer Discov (2021) 10.1158/2159-8290.cd-20-0775

[39]

Ozdemir "Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival" Cancer Cell (2015) 10.1016/j.ccell.2015.11.002

[40]

Rhim "Stanger BZ: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma" Cancer Cell (2014) 10.1016/j.ccr.2014.04.021

[41]

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Ingmar Mederacke, Christine C. Hsu, Juliane S. Troeger et al.

Nature Communications 2013 10.1038/ncomms3823

[42]

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

Bruno Cogliati, Chittampalli N. Yashaswini, Shuang Wang et al.

Nature Reviews Gastroenterology & Hepatology 2023 10.1038/s41575-023-00821-z

[43]

The Origin and Fate of Liver Myofibroblasts

Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor et al.

Cellular and Molecular Gastroenterology and Hepato... 2024 10.1016/j.jcmgh.2023.09.008

[44]

Puche "Hepatic stellate cells and liver fibrosis" Compr Physiol (2013) 10.1002/j.2040-4603.2013.tb00529.x

[45]

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva, David Brenner

Nature Reviews Gastroenterology & Hepatology 2021 10.1038/s41575-020-00372-7

[46]

Karin "The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis" Differentiation (2016) 10.1016/j.diff.2016.07.001

[47]

Affò "The role of cancer-associated fibroblasts and fibrosis in liver cancer" Annu Rev Pathol (2017) 10.1146/annurev-pathol-052016-100322

[48]

Zhang "Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials" Mol Cancer (2023) 10.1186/s12943-023-01860-5

[49]

Cadamuro "Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma" Hepatology (2013) 10.1002/hep.26384

[50]

Cadamuro "Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma" J Hepatol (2019) 10.1016/j.jhep.2018.12.004

Showing 50 of 201 references

Cited By

10

The Value of FAPI PET/CT in Cholangiocarcinoma and Pancreatic Cancer: An Update

Kim M. Pabst, Wolfgang P. Fendler · 2025

Seminars in Nuclear Medicine

Metrics

10

Citations

201

References

Details

Published: Mar 01, 2025
Vol/Issue: 195(3)
Pages: 378-396
License: View

Authors

Tumor Microenvironment Plasticity and Heterogeneity Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain

G

Gemma Garcia-Vicién

Tumor Microenvironment Plasticity and Heterogeneity Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

M

Massimiliano Cadamuro

School of Medicine and Surgery, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy; International Center for Digestive Health, University of Milano-Bicocca, 20126 Milano, Italy

Funding

European Commission Award: 101077312

Cancer Prevention and Research Institute of Texas Award: RP230204

Federación Española de Enfermedades Raras

Agencia Estatal de Investigación

MINISTERIO DE CIENCIA E INNOVACIÓN

Cite This Article

Silvia Affὸ, Laura Sererols-Viñas, Gemma Garcia-Vicién, et al. (2025). Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma. The American Journal of Pathology, 195(3), 378-396. https://doi.org/10.1016/j.ajpath.2024.07.009

Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

You May Also Like