The role of synovitis in osteoarthritis pathogenesis

Carla R. Scanzello; Steven R. Goldring

doi:10.1016/j.bone.2012.02.012

journal article Aug 01, 2012

The role of synovitis in osteoarthritis pathogenesis

Carla R. Scanzello Steven R. Goldring

Bone Vol. 51 No. 2 pp. 249-257 · Elsevier BV

View at Publisher Save 10.1016/j.bone.2012.02.012

Topics

No keywords indexed for this article. Browse by subject →

References

112

[1]

Abdollahi-Roodsaz "Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis" J Clin Invest (2008) 10.1172/jci32639

[2]

Akira "Toll-like receptor signalling" Nat Rev Immunol (2004) 10.1038/nri1391

[3]

Ayral "Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis — results of a 1year longitudinal arthroscopic study in 422 patients" Osteoarthritis Cartilage (2005) 10.1016/j.joca.2005.01.005

[4]

Baker "Relation of synovitis to knee pain using contrast-enhanced MRIs" Ann Rheum Dis (2010) 10.1136/ard.2009.121426

[5]

Barker "Fingerprinting the hyaluronic acid component of normal and pathological synovial fluids" Clin Chim Acta (1963) 10.1016/0009-8981(63)90013-5

[6]

Belcher "Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees" Ann Rheum Dis (1997) 10.1136/ard.56.5.299

[7]

Benito "Synovial tissue inflammation in early and late osteoarthritis" Ann Rheum Dis (2005) 10.1136/ard.2004.025270

[8]

Blom "Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3" Arthritis Rheum (2007) 10.1002/art.22337

[9]

Bock "The small proteoglycans decorin and biglycan in human articular cartilage of late-stage osteoarthritis" Osteoarthritis Cartilage (2001) 10.1053/joca.2001.0420

[10]

The role of synovial macrophages and macrophage‐produced mediators in driving inflammatory and destructive responses in osteoarthritis

Jan Bondeson, Arjen B. Blom, Shane Wainwright et al.

Arthritis & Rheumatism 2010 10.1002/art.27290

[11]

Borzi "Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C–X–C and C–C chemokines" Arthritis Rheum (2000) 10.1002/1529-0131(200008)43:8<1734::aid-anr9>3.0.co;2-b

[12]

Bradley "Synthesis of classical pathway complement components by chondrocytes" Immunology (1996)

[13]

Bresnihan "Synovium" (2009)

[14]

Bruhl "Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes" Rheumatology (Oxford) (2008) 10.1093/rheumatology/ken383

[15]

Cantatore "Early alteration of synovial membrane in osteoarthrosis" Clin Rheumatol (1988) 10.1007/bf02204457

[16]

Carrion "RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: immune regulation by vasoactive intestinal peptide" Arthritis Rheum (2011) 10.1002/art.30294

[17]

Chevalier "Presence of ED-A containing fibronectin in human articular cartilage from patients with osteoarthritis and rheumatoid arthritis" J Rheumatol (1996)

[18]

Chevalier "Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study" J Rheumatol (2005)

[19]

Chevalier "Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis" Arthritis Rheum (1994) 10.1002/art.1780370706

[20]

Cohen "A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL 1R1) in patients with osteoarthritis of the knee" Arthritis Res Ther (2011) 10.1186/ar3430

[21]

Conaghan "Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study" Ann Rheum Dis (2010) 10.1136/ard.2008.099564

[22]

Crawford "A case of chondromatosis indicates a synovial stem cell aetiology" Rheumatology (Oxford) (2006) 10.1093/rheumatology/kel111

[23]

Cs-Szabo "Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage" Arthritis Rheum (1995) 10.1002/art.1780380514

[24]

Cuellar "Diagnostic utility of cytokine biomarkers in the evaluation of acute knee pain" J Bone Joint Surg Am (2009) 10.2106/jbjs.h.00835

[25]

Dahl "Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies" Ann Rheum Dis (1985) 10.1136/ard.44.12.817

[26]

Dingle "A cartilage catabolic factor from synovium" Biochem J (1979) 10.1042/bj1840177

[27]

Ehrnthaller "New insights of an old defense system: structure, function, and clinical relevance of the complement system" Mol Med (2011) 10.2119/molmed.2010.00149

[28]

Endres "Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells" Osteoarthritis Cartilage (2010) 10.1016/j.joca.2010.08.003

[29]

Fan "Synovium-derived mesenchymal stem cells: a new cell source for musculoskeletal regeneration" Tissue Eng Part B Rev (2009) 10.1089/ten.teb.2008.0586

[30]

Fernandez-Madrid "Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis" Magn Reson Imaging (1995) 10.1016/0730-725x(94)00119-n

[31]

Fotinos-Hoyer "Assessment of synovitis in the osteoarthritic knee: comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI" Magn Reson Med (2010) 10.1002/mrm.22401

[32]

Fox "Cell-based meniscal tissue engineering: a case for synoviocytes" Clin Orthop Relat Res (2011) 10.1007/s11999-011-1824-z

[33]

Fujikawa "Interleukin-1 receptor antagonist production in cultured synovial cells from patients with rheumatoid arthritis and osteoarthritis" Ann Rheum Dis (1995) 10.1136/ard.54.4.318

[34]

Gobezie "High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis" Arthritis Res Ther (2007) 10.1186/ar2172

[35]

Goldberg "Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis" Arthritis Rheum (1991) 10.1002/art.1780340704

[36]

Goldenberg "Inflammatory synovitis in degenerative joint disease" J Rheumatol (1982)

[37]

Goldring "Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes" J Clin Invest (1988) 10.1172/jci113823

[38]

Goldring "Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis" Eur Cell Mater (2011) 10.22203/ecm.v021a16

[39]

Guermazi "Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study" Ann Rheum Dis (2011) 10.1136/ard.2010.139618

[40]

Happonen "Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis" Arthritis Rheum (2010) 10.1002/art.27720

[41]

Haringman "Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis" Ann Rheum Dis (2006) 10.1136/ard.2005.037176

[42]

Heiland "Synovial immunopathology in haemochromatosis arthropathy" Ann Rheum Dis (2010) 10.1136/ard.2009.120204

[43]

Hill "Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis" Ann Rheum Dis (2007) 10.1136/ard.2006.067470

[44]

Hui "A systems biology approach to synovial joint lubrication in health, injury, and disease" Wiley Interdiscip Rev Syst Biol Med (2011) 10.1002/wsbm.157

[45]

Hunter "The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score)" Ann Rheum Dis (2008) 10.1136/ard.2006.066183

[46]

Ishijima "Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis" Arthritis Res Ther (2011) 10.1186/ar3246

[47]

Innate Immune Recognition

Charles A. Janeway, Ruslan Medzhitov

Annual Review of Immunology 2002 10.1146/annurev.immunol.20.083001.084359

[48]

Jin "NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy" Proc Natl Acad Sci U S A (2011) 10.1073/pnas.1111101108

[49]

Jung "Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts" Immunol Lett (2007) 10.1016/j.imlet.2006.12.006

[50]

Kalchishkova "NC4 domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H" J Biol Chem (2011) 10.1074/jbc.m111.242834

Showing 50 of 112 references

Cited By

1,046

Concurrent joint contact in anterior cruciate ligament injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis

Kei Takahata, Yu-Yang Lin · 2026

Osteoarthritis and Cartilage

Guardians on call: neutrophils, macrophages and dendritic cells in arthritis pathogenesis

Navita Sharma, Jasika Bashal · 2025

Critical Reviews in Clinical Labora...

Articular Cartilage: Structure, Biomechanics, and the Potential of Conventional and Advanced Diagnostics

Robert Karpiński, Aleksandra Prus · 2025

Applied Sciences

Prospects for using orthobiologic products in knee osteoarthritis: а review

Andrey Yu. Ustyugov, Alexander N. Torgashin · 2025

N.N. Priorov Journal of Traumatolog...

Arthroscopic partial meniscectomy outcomes are comparable in patients with synovitis treated by synovectomy and those without synovitis

Kyle G. Williams, Evangelia P. Constantine · 2025

Knee Surgery, Sports Traumatology,...

Current cutting-edge omics techniques on musculoskeletal tissues and diseases

Xiaofei Li, Liang Fang · 2025

Bone Research

A Review and Meta‐Analysis of Biomarkers in Early‐Stage Osteoarthritis

Austin Lawrence, Joseph Boesel · 2025

Orthopaedic Surgery

Exosomes derived from miR-146a-overexpressing fibroblast-like synoviocytes in cartilage degradation and macrophage M1 polarization: a novel protective agent for osteoarthritis?

Huan Wang, Yue Zhang · 2024

Frontiers in Immunology

Bibliometric analysis of synovial in osteoarthritis in the last 10 years

Guangtao Han, Lijun Cai · 2024

Heliyon

Bidirectional association identified between synovitis and knee and hand osteoarthritis: a general population-based study

Ting Jiang, Qianlin Weng · 2024

The Lancet Regional Health - Wester...

Age-related bone diseases: Role of inflammaging

Jiaming Bi, Caimei Zhang · 2024

Journal of Autoimmunity

The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression

Hui Deng, Zhijun Chen · 2024

Scientific Reports

Macrophage Activation in Synovitis and Osteoarthritis of Temporomandibular Joint and Its Relationship with the Progression of Synovitis and Bone Remodeling

Shiyu Hu, Huimin Li · 2024

The American Journal of Pathology

Mechanisms of chondrocyte cell death in osteoarthritis: implications for disease progression and treatment

Mengqi Guan, Qingyuan Yu · 2024

Journal of Orthopaedic Surgery and...

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Zichang Liu, Yu Zhuang · 2023

Bioactive Materials

Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo

Tingwen Cai, Hantao Ye · 2023

International Immunopharmacology

Effects of platelet-rich plasma on subchondral bone marrow edema and biomarkers in synovial fluid of knee osteoarthritis

Wanchang Lin, Li Xie · 2023

The Knee

The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Qingluo Zhou, Qun Ren · 2022

Frontiers in Endocrinology

Diagnosis and Treatment of Hip and Knee Osteoarthritis

Jeffrey N. Katz, Kaetlyn R. Arant · 2021

JAMA

Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology

Susanne Grässel, Frank Zaucke · 2021

Journal of Clinical Medicine

Metrics

1,046

Citations

112

References

Details

Published: Aug 01, 2012
Vol/Issue: 51(2)
Pages: 249-257
License: View

Authors

Cite This Article

Carla R. Scanzello, Steven R. Goldring (2012). The role of synovitis in osteoarthritis pathogenesis. Bone, 51(2), 249-257. https://doi.org/10.1016/j.bone.2012.02.012

The role of synovitis in osteoarthritis pathogenesis

You May Also Like