The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Qingluo Zhou; Qun Ren; Linhui Jiao; Jishang Huang; Jun Yi; Jincai Chen; Jinliang Lai; Guanglin Ji; Tiansheng Zheng

doi:10.3389/fendo.2022.1069057

journal article Open Access Nov 24, 2022

The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Qingluo Zhou Qun Ren

Linhui Jiao Jishang Huang Jun Yi

Jincai Chen Jinliang Lai Guanglin Ji Tiansheng Zheng

Frontiers in Endocrinology Vol. 13 · Frontiers Media SA

View at Publisher Save 10.3389/fendo.2022.1069057

Abstract

Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.

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Published: Nov 24, 2022
Vol/Issue: 13
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Authors

School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

Cite This Article

Qingluo Zhou, Qun Ren, Linhui Jiao, et al. (2022). The potential roles of JAK/STAT signaling in the progression of osteoarthritis. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.1069057

The potential roles of JAK/STAT signaling in the progression of osteoarthritis

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