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References
66
[1]
Abdelhak "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family" Nat. Genet. (1997) 10.1038/ng0297-157
[2]
Ahmed "Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2" Dev. Cell (2012) 10.1016/j.devcel.2011.12.006
[3]
Auvergne "Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes" Cell Rep. (2013) 10.1016/j.celrep.2013.04.035
[4]
Blaess "Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region" Development (2006) 10.1242/dev.02339
[5]
Bok "Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear" Development (2007) 10.1242/dev.000760
[6]
Caspary "The graded response to Sonic Hedgehog depends on cilia architecture" Dev. Cell (2007) 10.1016/j.devcel.2007.03.004
[7]
Chan "Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses" Nat. Neurosci. (2009) 10.1038/nn.2287
[8]
Small molecule modulation of Smoothened activity

James K. Chen, Jussi Taipale, Keith E. Young et al.

Proceedings of the National Academy of Sciences 2002 10.1073/pnas.182542899
[9]
Christensen "The six family of homeobox genes in development and cancer" Adv. Cancer Res. (2008) 10.1016/s0065-230x(08)00405-3
[10]
Cohen "Targeting the hedgehog pathway: role in cancer and clinical implications of its inhibition" Hematol. Oncol. Clin. North Am. (2012) 10.1016/j.hoc.2012.01.005
[11]
Cook "Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions" Nature (2009) 10.1038/nature07849
[12]
Corrales "Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development" Development (2004) 10.1242/dev.01438
[13]
Dahmane "Sonic hedgehog regulates the growth and patterning of the cerebellum" Development (1999) 10.1242/dev.126.14.3089
[14]
El-Hashash "Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung" Dev. Biol. (2011) 10.1016/j.ydbio.2010.11.022
[15]
El-Hashash "Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium" Development (2011) 10.1242/dev.058479
[16]
Evangelista "Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction" Sci. Signal. (2008) 10.1126/scisignal.1162925
[17]
Goetz "The primary cilium: a signalling centre during vertebrate development" Nat. Rev. Genet. (2010) 10.1038/nrg2774
[18]
Goodrich "Altered neural cell fates and medulloblastoma in mouse patched mutants" Science (1997) 10.1126/science.277.5329.1109
[19]
Hallahan "The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas" Cancer Res. (2004) 10.1158/0008-5472.can-04-1813
[20]
Han "Dual and opposing roles of primary cilia in medulloblastoma development" Nat. Med. (2009) 10.1038/nm.2020
[21]
Hayden Gephart "Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma" J. Neurooncol. (2013) 10.1007/s11060-013-1216-1
[22]
Hillman "Neuropilins are positive regulators of Hedgehog signal transduction" Genes Dev. (2011) 10.1101/gad.173054.111
[23]
Hochman "Molecular pathways regulating pro-migratory effects of Hedgehog signaling" J. Biol. Chem. (2006) 10.1074/jbc.m605905200
[24]
Mechanisms and functions of Hedgehog signalling across the metazoa

Philip W. Ingham, Yoshiro Nakano, Claudia Seger

Nature Reviews Genetics 2011 10.1038/nrg2984
[25]
Jacob "Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling" Sci. Signal. (2011) 10.1126/scisignal.2001225
[26]
Jozefczuk "Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells" J. Vis. Exp. (2012)
[27]
Junker "A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning" Dev. Cell (2014) 10.1016/j.devcel.2014.10.017
[28]
Kochhar "Branchio-oto-renal syndrome" Am. J. Med. Genet. A. (2007) 10.1002/ajmg.a.31561
[29]
Kool "Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features" PLoS ONE (2008) 10.1371/journal.pone.0003088
[30]
Kool "Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition" Cancer Cell (2014) 10.1016/j.ccr.2014.02.004
[31]
Krishnan "Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent" J. Biol. Chem. (2009) 10.1074/jbc.c900032200
[32]
Krueger "Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity" J. Biomol. Screen. (2013) 10.1177/1087057112453936
[33]
Kumar "The molecular circuitry governing retinal determination" Biochim. Biophys. Acta (2009) 10.1016/j.bbagrm.2008.10.001
[34]
Larkins "Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins" Mol. Biol. Cell (2011) 10.1091/mbc.e10-12-0994
[35]
[36]
Liu "[Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry]" Se Pu (2010)
[37]
Liu "Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation" Nucleic Acids Res. (2010) 10.1093/nar/gkq585
[38]
Lu "Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling" Dev. Biol. (2013) 10.1016/j.ydbio.2013.07.019
[39]
Metcalfe "Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists" Cancer Res. (2011) 10.1158/0008-5472.can-11-0923
[40]
Mutsuddi "Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent" Genetics (2005) 10.1534/genetics.104.039156
[41]
Nieuwenhuis "Hedgehog signaling and congenital malformations" Clin. Genet. (2005) 10.1111/j.1399-0004.2004.00360.x
[42]
Northcott "Medulloblastoma comprises four distinct molecular variants" J. Clin. Oncol. (2011) 10.1200/jco.2009.27.4324
[43]
Nybakken "A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway" Nat. Genet. (2005) 10.1038/ng1682
[44]
Ozaki "Six1 controls patterning of the mouse otic vesicle" Development (2004) 10.1242/dev.00943
[45]
Pandey "The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells" Oncogene (2010) 10.1038/onc.2010.122
[46]
Patrick "Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome" Nat. Struct. Mol. Biol. (2013) 10.1038/nsmb.2505
[47]
Rayapureddi "Eyes absent represents a class of protein tyrosine phosphatases" Nature (2003) 10.1038/nature02093
[48]
Rebay "New vision from Eyes absent: transcription factors as enzymes" Trends Genet. (2005) 10.1016/j.tig.2005.01.005
[49]
Robinson "Novel mutations target distinct subgroups of medulloblastoma" Nature (2012) 10.1038/nature11213
[50]
Rodon "A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors" Clin. Cancer Res. (2014) 10.1158/1078-0432.ccr-13-1710

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Published
Apr 01, 2015
Vol/Issue
33(1)
Pages
22-35
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Cite This Article
Adriana Eisner, Maria F. Pazyra-Murphy, Ershela Durresi, et al. (2015). The Eya1 Phosphatase Promotes Shh Signaling during Hindbrain Development and Oncogenesis. Developmental Cell, 33(1), 22-35. https://doi.org/10.1016/j.devcel.2015.01.033
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