β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

Anton "Caloric restriction to moderate senescence: mechanisms and clinical utility" Curr. Transl. Geriatr. Exp. Gerontol. Rep. (2013) 10.1007/s13670-013-0062-5

[3]

Bredesen "Reversal of cognitive decline in Alzheimer’s disease" Aging (Albany NY) (2016) 10.18632/aging.100981

[4]

Buganim "Mechanisms and models of somatic cell reprogramming" Nat. Rev. Genet. (2013) 10.1038/nrg3473

[5]

Cai "In search of “stemness.”" Exp. Hematol. (2004) 10.1016/j.exphem.2004.03.013

[6]

Cherepanova "Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective" Nat. Med. (2016) 10.1038/nm.4109

[7]

Cheung "Molecular regulation of stem cell quiescence" Nat. Rev. Mol. Cell Biol. (2013) 10.1038/nrm3591

[8]

Childs "Cellular senescence in aging and age-related disease: from mechanisms to therapy" Nat. Med. (2015) 10.1038/nm.4000

[9]

Childs "Senescent intimal foam cells are deleterious at all stages of atherosclerosis" Science (2016) 10.1126/science.aaf6659

[10]

Choi "Heterogeneous nuclear ribonucleoprotein A2/B1 regulates the self-renewal and pluripotency of human embryonic stem cells via the control of the G1/S transition" Stem Cells (2013) 10.1002/stem.1366

[11]

Collado "Senescence in tumours: evidence from mice and humans" Nat. Rev. Cancer (2010) 10.1038/nrc2772

[12]

Colman "Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys" Nat. Commun. (2014) 10.1038/ncomms4557

[13]

Costantino "Ageing, metabolism and cardiovascular disease" J. Physiol. (2016) 10.1113/jp270538

[14]

Finkel "The common biology of cancer and ageing" Nature (2007) 10.1038/nature05985

[15]

Autophagy maintains stemness by preventing senescence

Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero et al.

Nature 2016 10.1038/nature16187

[16]

Guil "hnRNP A1 relocalization to the stress granules reflects a role in the stress response" Mol. Cell. Biol. (2006) 10.1128/mcb.00224-06

[17]

Hamilton "Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation" J. Biol. Chem. (1997) 10.1074/jbc.272.45.28732

[18]

Henics "Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins" J. Biol. Chem. (1994) 10.1016/s0021-9258(17)37697-4

[19]

Ito "The role of nucleophosmin in hematopoietic stem cells and the pathogenesis of myelodysplastic syndrome" Blood (2010) 10.1182/blood.v116.21.95.95

[20]

Jean-Philippe "hnRNP A1: the Swiss army knife of gene expression" Int. J. Mol. Sci. (2013) 10.3390/ijms140918999

[21]

Kellner "Transcriptional regulation of the Oct4 gene, a master gene for pluripotency" Histol. Histopathol. (2010)

[22]

Kim "Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts" Mol. Cell. Biol. (2013) 10.1128/mcb.00049-13

[23]

Kovacic "Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review" Circulation (2011) 10.1161/circulationaha.110.007021

[24]

Lengner "The pluripotency regulator Oct4: a role in somatic stem cells?" Cell Cycle (2008) 10.4161/cc.7.6.5573

[25]

Liu "Oxidative stress induces endothelial cell senescence via downregulation of Sirt6" BioMed Res. Int. (2014) 10.1155/2014/902842

[26]

Martin "Caloric restriction and intermittent fasting: two potential diets for successful brain aging" Ageing Res. Rev. (2006) 10.1016/j.arr.2006.04.002

[27]

Martin "Lamin B1 maintains the functional plasticity of nucleoli" J. Cell Sci. (2009) 10.1242/jcs.046284

[28]

Minamino "Vascular cell senescence: contribution to atherosclerosis" Circ. Res. (2007) 10.1161/01.res.0000256837.40544.4a

[29]

Minor "Dietary interventions to extend life span and health span based on calorie restriction" J. Gerontol. A Biol. Sci. Med. Sci. (2010) 10.1093/gerona/glq042

[30]

Ning "Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage" Mech. Ageing Dev. (2013) 10.1016/j.mad.2013.11.006

[31]

The Intersection Between Aging and Cardiovascular Disease

Brian J. North, David A. Sinclair

Circulation Research 2012 10.1161/circresaha.111.246876

[32]

Paoli "Ketogenic diet in neuromuscular and neurodegenerative diseases" BioMed Res. Int. (2014) 10.1155/2014/474296

[33]

Sadaie "Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition" Mol. Biol. Cell (2015) 10.1091/mbc.e15-01-0003

[34]

Saldivia "The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei" Cell Rep. (2016) 10.1016/j.celrep.2016.09.041

[35]

Salmenperä "Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells" Exp. Cell Res. (2016) 10.1016/j.yexcr.2016.05.005

[36]

Shimi "The role of nuclear lamin B1 in cell proliferation and senescence" Genes Dev. (2011) 10.1101/gad.179515.111

[37]

Spring "Chemical genetics to chemical genomics: small molecules offer big insights" Chem. Soc. Rev. (2005) 10.1039/b312875j

[38]

Stone "Paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction" N. Engl. J. Med. (2009) 10.1056/nejmoa0810116

[39]

Takahashi "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors" Cell (2006) 10.1016/j.cell.2006.07.024

[40]

Tchkonia "Cellular senescence and the senescent secretory phenotype: therapeutic opportunities" J. Clin. Invest. (2013) 10.1172/jci64098

[41]

Tian "Endothelial cell senescence and age-related vascular diseases" J. Genet. Genomics (2014) 10.1016/j.jgg.2014.08.001

[42]

Tieu "D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease" J. Clin. Invest. (2003) 10.1172/jci200318797

[43]

Uryga "Ageing induced vascular smooth muscle cell senescence in atherosclerosis" J. Physiol. (2016) 10.1113/jp270923

[44]

van Deursen "The role of senescent cells in ageing" Nature (2014) 10.1038/nature13193

[45]

Wang "Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence" Circ. Res. (2012) 10.1161/circresaha.111.261388

[46]

Will "Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment" Nat. Immunol. (2013) 10.1038/ni.2572

[47]

Williams "p53 in the DNA-damage-repair process" Cold Spring Harb. Perspect. Med. (2016) 10.1101/cshperspect.a026070

[48]

Wu "The role of BRCA1 in DNA damage response" Protein Cell (2010) 10.1007/s13238-010-0010-5

[49]

Xu "AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts" Biochim. Biophys. Acta (2015) 10.1016/j.bbamcr.2014.10.002

[50]

Yarden "BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage" Nat. Genet. (2002) 10.1038/ng837

Showing 50 of 51 references

Cited By

140

3D-Mesenchymal stromal cells derived VASH2 alleviates oxidative stress-induced endothelial senescence by mediating α-tubulin detyrosination in systemic sclerosis

Yue Zhang, Yirui Shi · 2026

Journal of Translational Medicine

Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome

Sachin Aryal, Blair Mell · 2025

American Journal of Physiology-Cell...

Identification of specific markers for human pluripotent stem cell‐derived small extracellular vesicles

Zhengsheng Chen, Lei Luo · 2024

Journal of Extracellular Vesicles

Ketone bodies in cell physiology and cancer

Giacomo Giuliani, Valter D. Longo · 2024

American Journal of Physiology-Cell...

The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle

Shubham Soni, Seyed Amirhossein Tabatabaei Dakhili · 2024

American Journal of Physiology-Cell...

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney

Souad Nasser, Thomas Solé · 2022

Molecular Metabolism

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

Daniel I. Benjamin, Pieter Both · 2022

Cell Metabolism

Beta-Hydroxybutyrate, Friend or Foe for Stressed Hearts

Yuxin Chu, Cheng Zhang · 2021

Frontiers in Aging

Metrics

140

Citations

51

References

Details

Published: Sep 01, 2018
Vol/Issue: 71(6)
Pages: 1064-1078.e5
License: View

Authors

Department of Microbiology & Immunology James Graham Brown Cancer Center University of Louisville Louisville KY USA

From the Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK (M.-J.X., P.S., N.S., B.L., J.X., M.-H.Z.); Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China (M.-J.X., X.W., Y.Z.); Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France (B.V.); Institut National de la Santé et de la Recherche Médicale, U1016 and U567, Paris, France (B.V.).

Cite This Article

Young-min Han, Tatiana Bedarida, Ye Ding, et al. (2018). β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Molecular Cell, 71(6), 1064-1078.e5. https://doi.org/10.1016/j.molcel.2018.07.036

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

You May Also Like