Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney

Souad Nasser; Thomas Solé; Nathalie Vega; Thierry Thomas; Aneta Balcerczyk; Maura Strigini; Luciano Pirola

doi:10.1016/j.molmet.2022.101578

journal article Open Access Nov 01, 2022

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney

Souad Nasser Thomas Solé Nathalie Vega Thierry Thomas Aneta Balcerczyk

Maura Strigini Luciano Pirola

Molecular Metabolism Vol. 65 pp. 101578 · Elsevier BV

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References

45

[1]

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Patrycja Puchalska, Peter A. Crawford

Cell Metabolism 2017 10.1016/j.cmet.2016.12.022

[2]

Nugent "Brain glucose and acetoacetate metabolism: a comparison of young and older adults" Neurobiology of Aging (2014) 10.1016/j.neurobiolaging.2013.11.027

[3]

Cuenoud "Metabolism of exogenous D-beta-hydroxybutyrate, an energy substrate avidly consumed by the heart and kidney" Frontiers in Nutrition (2020) 10.3389/fnut.2020.00013

[4]

Goldberg "β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares" Cell Reports (2017) 10.1016/j.celrep.2017.02.004

[5]

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Yun-Hee Youm, Kim Y Nguyen, Ryan W Grant et al.

Nature Medicine 2015 10.1038/nm.3804

[6]

Shimazu "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor" Science (New York, N.Y.) (2013) 10.1126/science.1227166

[7]

Chriett "Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule" Scientific Reports (2019) 10.1038/s41598-018-36941-9

[8]

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

Zhongyu Xie, Di Zhang, Dongjun Chung et al.

Molecular Cell 2016 10.1016/j.molcel.2016.03.036

[9]

Koronowski "Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation" Cell Reports (2021) 10.1016/j.celrep.2021.109487

[10]

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

Young-min Han, Tatiana Bedarida, Ye Ding et al.

Molecular Cell 2018 10.1016/j.molcel.2018.07.036

[11]

Weis "Ketone body oxidation increases cardiac endothelial cell proliferation" EMBO Molecular Medicine (2022) 10.15252/emmm.202114753

[12]

Veech "Ketone bodies mimic the life span extending properties of caloric restriction" IUBMB Life (2017) 10.1002/iub.1627

[13]

Neal "The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial" The Lancet Neurology (2008) 10.1016/s1474-4422(08)70092-9

[14]

Klepper "Glut1 deficiency syndrome (Glut1DS): state of the art in 2020 and recommendations of the international Glut1DS study group" Epilepsia Open (2020) 10.1002/epi4.12414

[15]

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

John C. Newman, Anthony J. Covarrubias, Minghao Zhao et al.

Cell Metabolism 2017 10.1016/j.cmet.2017.08.004

[16]

Buchhalter "The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy" Epilepsia Open (2017) 10.1002/epi4.12058

[17]

Operto "The ketogenic diet for the treatment of mood disorders in comorbidity with epilepsy in children and adolescents" Frontiers in Pharmacology (2020) 10.3389/fphar.2020.578396

[18]

Lauritzen "A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain" Neurobiology of Aging (2016) 10.1016/j.neurobiolaging.2016.08.005

[19]

Klement "Anti-tumor effects of ketogenic diets in mice: a meta-analysis" PLoS One (2016) 10.1371/journal.pone.0155050

[20]

Woolf "Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy" Frontiers in Molecular Neuroscience (2016) 10.3389/fnmol.2016.00122

[21]

Lussier "Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet" BMC Cancer (2016) 10.1186/s12885-016-2337-7

[22]

Raud "Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis" Scientific Reports (2020) 10.1038/s41598-020-60587-1

[23]

Fisher "Understanding the physiology of FGF21" Annual Review of Physiology (2016) 10.1146/annurev-physiol-021115-105339

[24]

Yano "Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice" Laboratory Investigation; a Journal of Technical Methods and Pathology (2022) 10.1038/s41374-021-00680-9

[25]

Erickson "The regulation of FGF21 gene expression by metabolic factors and nutrients" Hormone Molecular Biology and Clinical Investigation (2016) 10.1515/hmbci-2016-0016

[26]

Zhao "STAT3: a key regulator in liver fibrosis" Annals of Hepatology (2021) 10.1016/j.aohep.2020.06.010

[27]

Li "NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin" Theranostics (2021) 10.7150/thno.53652

[28]

Heymsfield "Mechanisms, pathophysiology, and management of obesity" New England Journal of Medicine (2017) 10.1056/nejmra1514009

[29]

Bray "NIH working group report-using genomic information to guide weight management: from universal to precision treatment" Obesity (Silver Spring, Md.) (2016) 10.1002/oby.21381

[30]

Dulloo "Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. Best Practice & Research" Clinics in Endocrinology and Metabolism (2008)

[31]

Aronica "Genetic variants for personalised management of very low carbohydrate ketogenic diets" BMJ Nutrition, Prevention & Health (2020) 10.1136/bmjnph-2020-000167

[32]

Roberts "A ketogenic diet extends longevity and healthspan in adult mice" Cell Metabolism (2017) 10.1016/j.cmet.2017.08.005

[33]

Kennedy "A high-fat, ketogenic diet induces a unique metabolic state in mice" American Journal of Physiology. Endocrinology and Metabolism (2007) 10.1152/ajpendo.00717.2006

[34]

Moriconi "Very-low-calorie ketogenic diet as a safe and valuable tool for long-term glycemic management in patients with obesity and type 2 diabetes" Nutrients (2021) 10.3390/nu13030758

[35]

Chakraborty "Salt-responsive metabolite, β-hydroxybutyrate, attenuates hypertension" Cell Reports (2018) 10.1016/j.celrep.2018.09.058

[36]

Ruppert "RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes" Life Science Alliance (2021) 10.26508/lsa.202101037

[37]

Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet

Paola Tognini, Mari Murakami, Yu Liu et al.

Cell Metabolism 2017 10.1016/j.cmet.2017.08.015

[38]

Venable "Fasting-induced renal HMGCS2 expression does not contribute to circulating ketones" American Journal of Physiology. Renal Physiology (2022) 10.1152/ajprenal.00447.2021

[39]

Asif "Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis" Molecular Metabolism (2022) 10.1016/j.molmet.2022.101494

[40]

Durrer "A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes" Nature Communications (2021) 10.1038/s41467-021-25667-4

[41]

Thomsen "Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial" Diabetologia (2022) 10.1007/s00125-021-05628-8

[42]

Barber "Obesity and polycystic ovary syndrome" Clinical Endocrinology (2021) 10.1111/cen.14421

[43]

Mavropoulos "The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study" Nutrition & Metabolism (2005) 10.1186/1743-7075-2-35

[44]

Cincione "Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome" International Journal of Environmental Research and Public Health (2021) 10.3390/ijerph182312490

[45]

Lorenzo "Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight" Clinical Nutrition (Edinburgh, Scotland) (2022) 10.1016/j.clnu.2022.05.007

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References

Details

Published: Nov 01, 2022
Vol/Issue: 65
Pages: 101578
License: View

Authors

Université Jean Monnet Saint-Étienne, CHU de Saint-Etienne, Rheumatology Department, INSERM U1059, F-42023, Saint-Etienne, France

Institute of Biochemistry, University of Fribourg, CH-1700 Fribourg, Switzerland.

Cite This Article

Souad Nasser, Thomas Solé, Nathalie Vega, et al. (2022). Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney. Molecular Metabolism, 65, 101578. https://doi.org/10.1016/j.molmet.2022.101578

Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney

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