Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

Baolei Jia; Yuanqiang Zou; Xiao Han; Jin-Woo Bae; Che Ok Jeon

doi:10.1016/j.tim.2022.08.003

journal article Jan 01, 2023

Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

Baolei Jia Yuanqiang Zou

Xiao Han

Jin-Woo Bae

Che Ok Jeon

Trends in Microbiology Vol. 31 No. 1 pp. 76-91 · Elsevier BV

View at Publisher Save 10.1016/j.tim.2022.08.003

Topics

No keywords indexed for this article. Browse by subject →

References

110

[1]

Virani "Heart disease and stroke statistics-2021 update" Circulation (2021) 10.1161/cir.0000000000000950

[2]

Goldstein "A century of cholesterol and coronaries: from plaques to genes to statins" Cell (2015) 10.1016/j.cell.2015.01.036

[3]

Song "Cholesterol-induced toxicity: an integrated view of the role of cholesterol in multiple diseases" Cell Metab. (2021) 10.1016/j.cmet.2021.09.001

[4]

Cohen "Balancing cholesterol synthesis and absorption in the gastrointestinal tract" J. Clin. Lipidol. (2008) 10.1016/j.jacl.2008.01.004

[5]

Ikonen "Mechanisms for cellular cholesterol transport: defects and human disease" Physiol. Rev. (2006) 10.1152/physrev.00022.2005

[6]

Barter "Variations in time to benefit among clinical trials of cholesterol-lowering drugs" J. Clin. Lipidol. (2018) 10.1016/j.jacl.2018.04.006

[7]

Brown "Microbial modulation of cardiovascular disease" Nat. Rev. Microbiol. (2018) 10.1038/nrmicro.2017.149

[8]

Le Roy "The intestinal microbiota regulates host cholesterol homeostasis" BMC Biol. (2019) 10.1186/s12915-019-0715-8

[9]

Hill "The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic" Nat. Rev. Gastroenterol. Hepatol. (2014) 10.1038/nrgastro.2014.66

[10]

Suez "The pros, cons, and many unknowns of probiotics" Nat. Med. (2019) 10.1038/s41591-019-0439-x

[11]

O'Toole "Next-generation probiotics: the spectrum from probiotics to live biotherapeutics" Nat. Microbiol. (2017) 10.1038/nmicrobiol.2017.57

[12]

Martín "Emerging health concepts in the probiotics field: streamlining the definitions" Front. Microbiol. (2019) 10.3389/fmicb.2019.01047

[13]

Aron-Wisnewsky "Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity?" Gastroenterology (2020) 10.1053/j.gastro.2020.01.049

[14]

Kazemian "Gut microbiota and cardiovascular disease: opportunities and challenges" Microbiome (2020) 10.1186/s40168-020-00821-0

[15]

Zoetendal "The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates" ISME J. (2012) 10.1038/ismej.2011.212

[16]

Zhao "Structure-specific effects of short-chain fatty acids on plasma cholesterol concentration in male syrian hamsters" J. Agric. Food Chem. (2017) 10.1021/acs.jafc.7b04666

[17]

Louis "Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene" Environ. Microbiol. (2010) 10.1111/j.1462-2920.2009.02066.x

[18]

Kasahara "Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model" Nat. Microbiol. (2018) 10.1038/s41564-018-0272-x

[19]

Tan "Investigations of Bacteroides spp. towards next-generation probiotics" Food Res. Int. (2019) 10.1016/j.foodres.2018.08.088

[20]

Stoeva "Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease" Gut Microbes (2021) 10.1080/19490976.2021.1907272

[21]

Alvaro "Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids" IUBMB Life (2008) 10.1002/iub.110

[22]

Hara "Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine" J. Nutr. (1999) 10.1093/jn/129.5.942

[23]

Fushimi "Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet" Br. J. Nutr. (2006) 10.1079/bjn20061740

[24]

Du "Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice" Br. J. Pharmacol. (2020) 10.1111/bph.14933

[25]

de Boer "Cholesterol transport revisited: a new turbo mechanism to drive cholesterol excretion" Trends Endocrinol. Metab. (2018) 10.1016/j.tem.2017.11.006

[26]

Yamanashi "Novel function of Niemann–Pick C1-like 1 as a negative regulator of Niemann–Pick C2 protein" Hepatology (2012) 10.1002/hep.24772

[27]

Haghikia "Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism" Eur. Heart J. (2022) 10.1093/eurheartj/ehab644

[28]

Chen "Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice" J. Nutr. Biochem. (2018) 10.1016/j.jnutbio.2018.02.011

[29]

Li "Novel insights: dynamic foam cells derived from the macrophage in atherosclerosis" J. Cell. Physiol. (2021) 10.1002/jcp.30300

[30]

Xiong "Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41" Proc. Natl. Acad. Sci. U. S. A. (2004) 10.1073/pnas.2637002100

[31]

Stern "Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk" Cell Metab. (2016) 10.1016/j.cmet.2016.04.011

[32]

Jiao "Short chain fatty acids could prevent fat deposition in pigs via regulating related hormones and genes" Food Funct. (2020) 10.1039/c9fo02585e

[33]

Chiang "Bile acid metabolism and signaling" Compr. Physiol. (2013) 10.1002/j.2040-4603.2013.tb00517.x

[34]

Jia "Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health" Gut Microbes (2020) 10.1080/19490976.2020.1748261

[35]

Marion "Biogeography of microbial bile acid transformations along the murine gut" J. Lipid Res. (2020) 10.1194/jlr.ra120001021

[36]

Daly "Functional and phylogenetic diversity of BSH and PVA enzymes" Microorganisms (2021) 10.3390/microorganisms9040732

[37]

Choi "Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario" Crit. Rev. Biotechnol. (2015) 10.3109/07388551.2014.889077

[38]

Jia "Diet-related alterations of gut bile salt hydrolases determined using a metagenomic analysis of the human microbiome" Int. J. Mol. Sci. (2021) 10.3390/ijms22073652

[39]

Joyce "Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut" Proc. Natl. Acad. Sci. U. S. A. (2014) 10.1073/pnas.1323599111

[40]

Yao "A selective gut bacterial bile salt hydrolase alters host metabolism" eLife (2018) 10.7554/elife.37182

[41]

Winston "Diversification of host bile acids by members of the gut microbiota" Gut Microbes (2020) 10.1080/19490976.2019.1674124

[42]

Hamilton "Human cecal bile acids: concentration and spectrum" Am. J. Physiol. Gastrointest. (2007) 10.1152/ajpgi.00027.2007

[43]

Sato "Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians" Nature (2021) 10.1038/s41586-021-03832-5

[44]

Jia "Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids" PLoS Pathog. (2019) 10.1371/journal.ppat.1007954

[45]

Hartman "Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR–/– and apoE–/– mice" J. Lipid Res. (2009) 10.1194/jlr.m800619-jlr200

[46]

Kim "Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2" Genome Biol. (2015) 10.1186/s13059-015-0835-6

[47]

de Boer "Intestinal farnesoid X receptor controls transintestinal cholesterol excretion in mice" Gastroenterology (2017) 10.1053/j.gastro.2016.12.037

[48]

Li "Irisin is controlled by farnesoid X receptor and regulates cholesterol homeostasis" Front. Pharmacol. (2019) 10.3389/fphar.2019.00548

[49]

Xu "Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice" Hepatology (2016) 10.1002/hep.28712

[50]

Pols "The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation" J. Hepatol. (2011) 10.1016/j.jhep.2010.12.004

Showing 50 of 110 references

Cited By

167

The causal relationship between brown rice, gut microbiota, and blood lipid levels: Insights from Mendelian randomization study

Qi Zheng, Yuetong Li · 2026

Microbial Pathogenesis

Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential

Li-Min Liu, Xiao-fei He · 2026

Acta Pharmacologica Sinica

Probiotics and triglyceride manipulation: potential implications for alleviating hypertriglyceridemia

Mingliang Zhang, Weimin Jiang · 2026

Journal of Advanced Research

A gut feeling of statin

Jianqing She, Lizhe Sun · 2024

Gut Microbes

Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Daojie Li, Hongying Cai · 2024

Journal of Animal Science and Biote...

Sickle Cell Disease and Gut Health: The Influence of Intestinal Parasites and the Microbiome on Angolan Children

Mariana Delgadinho, Catarina Ginete · 2024

International Journal of Molecular...

Association of Life's Essential 8 with osteoarthritis in United States adults: mediating effects of dietary intake of live microbes

Ruoyu Gou, Xiaoyu Chang · 2023

Frontiers in Medicine

Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals

Najaf Amin, Jun Liu · 2023

JAMA Psychiatry

Probiotics Increase Intramuscular Fat and Improve the Composition of Fatty Acids in Sunit Sheep through the Adenosine 5′-Monophosphate-Activated Protein Kinase (AMPK) Signaling Pathway

Yue Zhang, Duo Yao · 2023

Food Science of Animal Resources

Metrics

167

Citations

110

References

Details

Published: Jan 01, 2023
Vol/Issue: 31(1)
Pages: 76-91
License: View

Authors

National Engineering Laboratory for Cereal Fermentation Technology, School of Food Science and Technology Jiangnan University Wuxi China; Jiangsu Industrial Technology Research Institute Jiangnan University (Rugao) Food Biotechnology Research Institute Nantong China

J

Jin-Woo Bae

Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 130-701, Republic of Korea

C

Che Ok Jeon

Department of Life Science, Chung-Ang University, Seoul 156-756, Korea

Cite This Article

Baolei Jia, Yuanqiang Zou, Xiao Han, et al. (2023). Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease. Trends in Microbiology, 31(1), 76-91. https://doi.org/10.1016/j.tim.2022.08.003

Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

You May Also Like