The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

Trevor N. Stitt; Doreen Drujan; Brian A. Clarke; Frank Panaro; Yekatarina Timofeyva; William O. Kline; Michael Gonzalez; George D. Yancopoulos; David J. Glass

doi:10.1016/s1097-2765(04)00211-4

journal article Open Access May 01, 2004

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

Trevor N. Stitt Doreen Drujan Brian A. Clarke Frank Panaro Yekatarina Timofeyva William O. Kline Michael Gonzalez

George D. Yancopoulos David J. Glass

Molecular Cell Vol. 14 No. 3 pp. 395-403 · Elsevier BV

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References

35

[1]

Adams "Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats" J. Appl. Physiol. (1998) 10.1152/jappl.1998.84.5.1716

[2]

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Sue C. Bodine, Esther Latres, Susanne Baumhueter et al.

Science 2001 10.1126/science.1065874

[3]

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez et al.

Nature Cell Biology 2001 10.1038/ncb1101-1014

[4]

Bois "FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts" EMBO J. (2003) 10.1093/emboj/cdg116

[5]

Brunet "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor" Cell (1999) 10.1016/s0092-8674(00)80595-4

[6]

The Phosphoinositide 3-Kinase Pathway

Lewis C. Cantley

Science 2002 10.1126/science.296.5573.1655

[7]

Carlsson "Forkhead transcription factors" Dev. Biol. (2002) 10.1006/dbio.2002.0780

[8]

Coleman "Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice" J. Biol. Chem. (1995) 10.1074/jbc.270.20.12109

[9]

Cross "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B" Nature (1995) 10.1038/378785a0

[10]

Datta "Cellular survival" Genes Dev. (1999) 10.1101/gad.13.22.2905

[11]

DeVol "Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth" Am. J. Physiol. (1990)

[12]

Du "Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kappa B" J. Biol. Chem. (2000) 10.1074/jbc.m907258199

[13]

Florini "Growth hormone and the insulin-like growth factor system in myogenesis" Endocr. Rev. (1996)

[14]

Glass "Signalling pathways that mediate skeletal muscle hypertrophy and atrophy" Nat. Cell Biol. (2003) 10.1038/ncb0203-87

[15]

Goldspink "Protein turnover measured in vivo and in vitro in muscles undergoing compensatory growth and subsequent denervation atrophy" Biochem. J. (1983) 10.1042/bj2100089

[16]

Gomes "Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy" Proc. Natl. Acad. Sci. USA (2001) 10.1073/pnas.251541198

[17]

Hasselgren "Glucocorticoids and muscle catabolism" Curr. Opin. Clin. Nutr. Metab. Care (1999) 10.1097/00075197-199905000-00002

[18]

Hong "Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures" Mol. Cell. Endocrinol. (1995) 10.1016/0303-7207(95)03476-n

[19]

Hribal "Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors" J. Cell Biol. (2003) 10.1083/jcb.200212107

[20]

Jagoe "What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?" Curr. Opin. Clin. Nutr. Metab. Care (2001) 10.1097/00075197-200105000-00003

[21]

Kops "Direct control of the Forkhead transcription factor AFX by protein kinase B" Nature (1999) 10.1038/19328

[22]

Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

William E. Mitch, Alfred L. Goldberg

New England Journal of Medicine 1996 10.1056/nejm199612193352507

[23]

Murgia "Ras is involved in nerve-activity-dependent regulation of muscle genes" Nat. Cell Biol. (2000) 10.1038/35004013

[24]

Musaro "Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle" Nat. Genet. (2001) 10.1038/84839

[25]

Nave "Mammalian target of rapamycin is a direct target for protein kinase B" Biochem. J. (1999) 10.1042/0264-6021:3440427

[26]

Pallafacchina "A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification" Proc. Natl. Acad. Sci. USA (2002) 10.1073/pnas.142166599

[27]

Reynolds "Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load" J. Biol. Chem. (2002) 10.1074/jbc.m201142200

[28]

Rommel "Differentiation stage-specific inhibition of the raf-MEK-ERK pathway by Akt" Science (1999) 10.1126/science.286.5445.1738

[29]

Rommel "Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways" Nat. Cell Biol. (2001) 10.1038/ncb1101-1009

[30]

Sandri "Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy" Cell (2004) 10.1016/s0092-8674(04)00400-3

[31]

Scott "Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3–L1 adipocytes" J. Biol. Chem. (1998) 10.1074/jbc.273.51.34496

[32]

Tran, H., Brunet, A., Griffith, E.C., and Greenberg, M.E. (2003). The many forks in FOXO's road. Sci. STKE 2003, RE5. 10.1126/stke.2003.172.re5

[33]

Vivanco "The phosphatidylinositol 3-kinase AKT pathway in human cancer" Nat. Rev. Cancer (2002) 10.1038/nrc839

[34]

Wang "Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes" Shock (1998) 10.1097/00024382-199810000-00011

[35]

Wray "Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle" Int. J. Biochem. Cell Biol. (2003) 10.1016/s1357-2725(02)00341-2

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Details

Published: May 01, 2004
Vol/Issue: 14(3)
Pages: 395-403
License: View

Authors

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.

George D. Yancopoulos

Regeneron Pharmaceuticals Inc, Tarrytown, New York

D

David J. Glass

Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

Cite This Article

Trevor N. Stitt, Doreen Drujan, Brian A. Clarke, et al. (2004). The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors. Molecular Cell, 14(3), 395-403. https://doi.org/10.1016/s1097-2765(04)00211-4

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

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