journal article Open Access Sep 10, 2019

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle

View at Publisher Save 10.3389/fnut.2019.00146
Topics

No keywords indexed for this article. Browse by subject →

References
90
[1]
Santilli "Clinical definition of sarcopenia" Clin Cases Min Bone Metabol. (2014) 10.11138/ccmbm/2014.11.3.177
[2]
Janssen "Evolution of sarcopenia research" Appl Physiol Nutr Metabol. (2010) 10.1139/h10-067
[3]
Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies

Gita Shafiee, Abbasali Keshtkar, Akbar Soltani et al.

Journal of Diabetes & Metabolic Disorders 2017 10.1186/s40200-017-0302-x
[4]
The Healthcare Costs of Sarcopenia in the United States

Ian Janssen, Donald S. Shepard, Peter T. Katzmarzyk et al.

Journal of the American Geriatrics Society 2004 10.1111/j.1532-5415.2004.52014.x
[5]
Pinedo-Villanueva "Health care costs associated with muscle weakness: a UK population-based estimate" Calcif Tissue Int. (2019) 10.1007/s00223-018-0478-1
[6]
Phillips "Dietary protein to support anabolism with resistance exercise in young men" J Am Coll Nutr. (2005) 10.1080/07315724.2005.10719454
[7]
Tipton "Exercise, protein metabolism, and muscle growth" Int J Sport Nutr Exerc Metab. (2001) 10.1123/ijsnem.11.1.109
[8]
Fry "Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis" Skelet Muscle. (2011) 10.1186/2044-5040-1-11
[9]
Fiatarone "High-intensity strength training in nonagenarians: Effects on skeletal muscle" JAMA. (1990) 10.1001/jama.1990.03440220053029
[10]
Biolo "Short-term bed rest impairs amino acid-induced protein anabolism in humans" J Physiol. (2004) 10.1113/jphysiol.2004.066365
[11]
Wall "Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion" PLoS ONE. (2015) 10.1371/journal.pone.0140903
[12]
Breen "Skeletal muscle protein metabolism in the elderly: Interventions to counteract the'anabolic resistance'of ageing" Nutr Metab. (2011) 10.1186/1743-7075-8-68
[13]
Backx "Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men" Nutrients. (2018) 10.3390/nu10050635
[14]
Glover "Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion" J Physiol. (2008) 10.1113/jphysiol.2008.160333
[15]
Abou Sawan "Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise" (2018)
[16]
Manifava "Dynamics of mTORC1 activation in response to amino acids" Elife. (2016) 10.7554/elife.19960
[17]
Deldicque "Regulation of mTOR by amino acids and resistance exercise in skeletal muscle" Eur J Appl Physiol. (2005) 10.1007/s00421-004-1255-6
[18]
Burd "Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young Men−3" J Nutr. (2011) 10.3945/jn.110.135038
[19]
Song "Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle" Sci Rep. (2017) 10.1038/s41598-017-05483-x
[20]
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

Daniel Cuthbertson, John Babraj, Graham Leese et al.

The FASEB Journal 2005 10.1096/fj.04-2640fje
[21]
Kumar "Age-related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men" J Physiol. (2009) 10.1113/jphysiol.2008.164483
[22]
Wen "Ribosome biogenesis is necessary for skeletal muscle hypertrophy" Exerc Sport Sci Rev. (2016) 10.1249/jes.0000000000000082
[23]
Latres "Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin (PI3K/akt/mTOR) pathway" J Biol Chem. (2005) 10.1074/jbc.m407517200
[24]
Hong "PtdIns3P controls mTORC1 signaling through lysosomal positioning" J Cell Biol. (2017) 10.1083/jcb.201611073
[25]
Chakraborty "Inositol pyrophosphates inhibit akt signaling, thereby regulating insulin sensitivity and weight gain" Cell. (2010) 10.1016/j.cell.2010.11.032
[26]
Naufahu "High intensity exercise decreases IP6K1 muscle content and improves insulin sensitivity (SI2*) in glucose intolerant individuals" J Clin Endocrinol Metab. (2018) 10.1210/jc.2017-02019
[27]
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

Trevor N. Stitt, Doreen Drujan, Brian A. Clarke et al.

Molecular Cell 2004 10.1016/s1097-2765(04)00211-4
[28]
Rinderknecht "Primary structure of human insulin-like growth factor II" FEBS Lett. (1978) 10.1016/0014-5793(78)80237-3
[29]
Turner "Induction of mRNA for IGF-I and-II during growth hormone-stimulated muscle hypertrophy" Am J Physiol Endocrinol Metabol. (1988) 10.1152/ajpendo.1988.255.4.e513
[30]
Barton "Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production" FASEB J. (2012) 10.1096/fj.11-203026
[31]
Sjögren "Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice" Proc Natl Acad Sci USA. (1999) 10.1073/pnas.96.12.7088
[32]
Yakar "Normal growth and development in the absence of hepatic insulin-like growth factor I" (1999)
[33]
Cohick "The insulin-like growth factors" Annu. Rev. Physiol. (1993) 10.1146/annurev.ph.55.030193.001023
[34]
Huffman "Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline" Aging Cell. (2016) 10.1111/acel.12415
[35]
Morton "Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men" J Appl Physiol. (2016) 10.1152/japplphysiol.00154.2016
[36]
West "Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state" J Appl Physiol. (2012) 10.1152/japplphysiol.00170.2012
[37]
Morton "Muscle androgen receptor content but not systemic hormones is associated with resistance training-induced skeletal muscle hypertrophy in healthy, young men" Front Physiol. (2018) 10.3389/fphys.2018.01373
[38]
Morimoto "Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors" Cancer Epidemiol Prevent Biomark. (2005) 10.1158/1055-9965.epi-04-0694
[39]
Jones "Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I" J Cell Biol. (1993) 10.1083/jcb.121.3.679
[40]
Hede "E-peptides control bioavailability of IGF-1" PLoS ONE. (2012) 10.1371/journal.pone.0051152
[41]
Philippou "Optimizing IGF-I for skeletal muscle therapeutics" Growth Hormone IGF Res. (2014) 10.1016/j.ghir.2014.06.003
[42]
O'Neill "Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis" Cell Rep. (2015) 10.1016/j.celrep.2015.04.037
[43]
Schiaffino "Regulation of skeletal muscle growth by the IGF1-akt/PKB pathway: Insights from genetic models" Skelet Muscle. (2011) 10.1186/2044-5040-1-4
[44]
Manning "Insulin signaling: Inositol phosphates get into the akt" Cell. (2010) 10.1016/j.cell.2010.11.040
[45]
Faissner "DSD-1-proteoglycan/phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues" (2006) 10.1007/0-387-30128-3_3
[46]
Lai "Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy" Mol Cell Biol. (2004) 10.1128/mcb.24.21.9295-9304.2004
[47]
Garofalo "Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta" J Clin Invest. (2003) 10.1172/jci16885
[48]
Easton "Role for Akt3/protein kinase bγ in attainment of normal brain size" Mol Cell Biol. (2005) 10.1128/mcb.25.5.1869-1878.2005
[49]
Diez "Specific roles of akt iso forms in apoptosis and axon growth regulation in neurons" PLoS ONE. (2012) 10.1371/journal.pone.0032715
[50]
Liu "PtdIns (3:4, 5) P3-dependent activation of the mTORC2 kinase complex" Cancer Discov. (2015) 10.1158/2159-8290.cd-15-0460

Showing 50 of 90 references

Metrics
133
Citations
90
References
Details
Published
Sep 10, 2019
Vol/Issue
6
License
View
Cite This Article
Richie D. Barclay, Nicholas A. Burd, Christopher Tyler, et al. (2019). The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle. Frontiers in Nutrition, 6. https://doi.org/10.3389/fnut.2019.00146
Related

You May Also Like

The Effects of Vegetarian and Vegan Diets on Gut Microbiota

Aleksandra Tomova, Igor Bukovsky · 2019

607 citations

The Myth of Cultured Meat: A Review

Sghaier Chriki, Jean-François Hocquette · 2020

416 citations