Correlation of Anti-HIV Activity with Anion Spacing in a Series of Cosalane Analogues with Extended Polycarboxylate Pharmacophores

Kalpathy C. Santhosh; Gitendra C. Paul; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw; Tracy L. Loftus; Jim A. Turpin; Robert W. Buckheit,; Mark Cushman

doi:10.1021/jm000290u

journal article Jan 19, 2001

Correlation of Anti-HIV Activity with Anion Spacing in a Series of Cosalane Analogues with Extended Polycarboxylate Pharmacophores

Kalpathy C. Santhosh Gitendra C. Paul Erik De Clercq

Christophe Pannecouque Myriam Witvrouw Tracy L. Loftus Jim A. Turpin Robert W. Buckheit, Mark Cushman

Journal of Medicinal Chemistry Vol. 44 No. 5 pp. 703-714 · American Chemical Society (ACS)

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Details

Published: Jan 19, 2001
Vol/Issue: 44(5)
Pages: 703-714

Authors

K

Kalpathy C. Santhosh

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

G

Gitendra C. Paul

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

E

Erik De Clercq

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

C

Christophe Pannecouque

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

M

Myriam Witvrouw

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

T

Tracy L. Loftus

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

J

Jim A. Turpin

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

R

Robert W. Buckheit,

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

M

Mark Cushman

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium, and Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701

Cite This Article

Kalpathy C. Santhosh, Gitendra C. Paul, Erik De Clercq, et al. (2001). Correlation of Anti-HIV Activity with Anion Spacing in a Series of Cosalane Analogues with Extended Polycarboxylate Pharmacophores. Journal of Medicinal Chemistry, 44(5), 703-714. https://doi.org/10.1021/jm000290u

Correlation of Anti-HIV Activity with Anion Spacing in a Series of Cosalane Analogues with Extended Polycarboxylate Pharmacophores

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