House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

HAMIDA HAMMAD; Marcello Chieppa; Frederic Perros; Monique A Willart; Ronald N Germain; Bart N Lambrecht

doi:10.1038/nm.1946

journal article Mar 29, 2009

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

HAMIDA HAMMAD Marcello Chieppa

Frederic Perros Monique A Willart Ronald N Germain Bart N Lambrecht

Nature Medicine Vol. 15 No. 4 pp. 410-416 · Springer Science and Business Media LLC

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References

45

[1]

Barnes, P.J. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 8, 183–192 (2008). 10.1038/nri2254

[2]

Vermaelen, K.Y., Carro-Muino, I., Lambrecht, B.N. & Pauwels, R.A. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193, 51–60 (2001). 10.1084/jem.193.1.51

[3]

Stampfli, M.R. et al. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J. Clin. Invest. 102, 1704–1714 (1998). 10.1172/jci4160

[4]

Ziegler, S.F. & Liu, Y.J. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat. Immunol. 7, 709–714 (2006). 10.1038/ni1360

[5]

Sha, Q. et al. Activation of airway epithelial cells by Toll-like receptor agonists. Am. J. Respir. Cell Mol. Biol. 31, 358–364 (2004). 10.1165/rcmb.2003-0388oc

[6]

Guillot, L. et al. Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J. Biol. Chem. 279, 2712–2718 (2004). 10.1074/jbc.m305790200

[7]

Skerrett, S.J. et al. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L143–L152 (2004). 10.1152/ajplung.00030.2004

[8]

Hammad, H. & Lambrecht, B.N. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8, 193–204 (2008). 10.1038/nri2275

[9]

Saito, T. et al. Expression of Toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouse. Cell Tissue Res. 321, 75–88 (2005). 10.1007/s00441-005-1113-9

[10]

Berndt, A. et al. Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L936–L943 (2007). 10.1152/ajplung.00394.2006

[11]

Trompette, A. et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457, 585–588 (2009). 10.1038/nature07548

[12]

Reis E Sousa, C. Dendritic cells in a mature age. Nat. Rev. Immunol. 6, 476–483 (2006). 10.1038/nri1845

[13]

Braun-Fahrlander, C. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med. 347, 869–877 (2002). 10.1056/nejmoa020057

[14]

Lewkowich, I.P. et al. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J. Exp. Med. 202, 1549–1561 (2005). 10.1084/jem.20051506

[15]

Fattouh, R. et al. House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. Am. J. Respir. Crit. Care Med. 172, 314–321 (2005). 10.1164/rccm.200502-198oc

[16]

Cates, E.C. et al. Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF–mediated mechanism. J. Immunol. 173, 6384–6392 (2004). 10.4049/jimmunol.173.10.6384

[17]

Fallon, P.G. et al. Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105–1116 (2006). 10.1084/jem.20051615

[18]

Kondo, Y. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int. Immunol. 20, 791–800 (2008). 10.1093/intimm/dxn037

[19]

Zhou, B. et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 6, 1047–1053 (2005). 10.1038/ni1247

[20]

Eisenbarth, S.C. et al. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645–1651 (2002). 10.1084/jem.20021340

[21]

Nolte, M.A., Leibundgut-Landmann, S., Joffre, O. & Sousa, C.R. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J. Exp. Med. 204, 1487–1501 (2007). 10.1084/jem.20070325

[22]

Poynter, M.E., Irvin, C.G. & Janssen-Heininger, Y.M. A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation. J. Immunol. 170, 6257–6265 (2003). 10.4049/jimmunol.170.12.6257

[23]

Noulin, N. et al. Both hematopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J. Immunol. 175, 6861–6869 (2005). 10.4049/jimmunol.175.10.6861

[24]

Lorenz, E. et al. Genes other than TLR4 are involved in the response to inhaled LPS. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L1106–L1114 (2001). 10.1152/ajplung.2001.281.5.l1106

[25]

Pichavant, M. et al. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J. Allergy Clin. Immunol. 115, 771–778 (2005). 10.1016/j.jaci.2004.11.043

[26]

Nathan, A.T., Peterson, E.A., Chakir, J. & Wills-Karp, M. Innate immune responses of airway epithelium to house dust mite are mediated through β-glucan–dependent pathways. J. Allergy Clin. Immunol. published online, doi:10.1016/j.jaci.2008.12.006 (27 January 2009). 10.1016/j.jaci.2008.12.006

[27]

Robays, L.J. et al. Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J. Immunol. 178, 5305–5311 (2007). 10.4049/jimmunol.178.8.5305

[28]

Geissmann, F., Jung, S. & Littman, D.R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19, 71–82 (2003). 10.1016/s1074-7613(03)00174-2

[29]

Veres, T.Z. et al. Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 37, 553–561 (2007). 10.1165/rcmb.2007-0087oc

[30]

Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration and territoriality in lymph nodes. Immunity 25, 989–1001 (2006). 10.1016/j.immuni.2006.10.011

[31]

Hammad, H. & Lambrecht, B.N. Lung dendritic cell migration. Adv. Immunol. 93, 265–278 (2007). 10.1016/s0065-2776(06)93007-7

[32]

Stumbles, P.A. et al. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (TH2) responses and require obligatory cytokine signals for induction of TH1 immunity. J. Exp. Med. 188, 2019–2031 (1998). 10.1084/jem.188.11.2019

[33]

Bilyk, N. & Holt, P.G. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony–stimulating factor. J. Exp. Med. 177, 1773–1777 (1993). 10.1084/jem.177.6.1773

[34]

Piggott, D.A. et al. MyD88-dependent induction of allergic TH2 responses to intranasal antigen. J. Clin. Invest. 115, 459–467 (2005). 10.1172/jci200522462

[35]

Liu, Y.J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med. 203, 269–273 (2006). 10.1084/jem.20051745

[36]

Angkasekwinai, P. et al. Interleukin 25 promotes the initiation of proallergic type 2 responses. J. Exp. Med. 204, 1509–1517 (2007). 10.1084/jem.20061675

[37]

Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9, 310–318 (2008). 10.1038/ni1558

[38]

Schmitz, J. et al. IL-33, an interleukin-1–like cytokine that signals via the IL-1 receptor–related protein ST2 and induces T helper type 2–associated cytokines. Immunity 23, 479–490 (2005). 10.1016/j.immuni.2005.09.015

[39]

Interleukin-13: Central Mediator of Allergic Asthma

Marsha Wills-Karp, Jackie Luyimbazi, Xueying Xu et al.

Science 1998 10.1126/science.282.5397.2258

[40]

Beutler, B. & Poltorak, A. The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity. Drug Metab. Dispos. 29, 474–478 (2001).

[41]

Boes, M. et al. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418, 983–988 (2002). 10.1038/nature01004

[42]

Matute-Bello, G. et al. Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice. J. Immunol. Methods 292, 25–34 (2004). 10.1016/j.jim.2004.05.010

[43]

Lambrecht, B.N., Salomon, B., Klatzmann, D. & Pauwels, R.A. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J. Immunol. 160, 4090–4097 (1998). 10.4049/jimmunol.160.8.4090

[44]

Van Rijt, L.S. et al. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J. Immunol. Methods 288, 111–121 (2004). 10.1016/j.jim.2004.03.004

[45]

Hammad, H. et al. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J. Exp. Med. 204, 357–367 (2007). 10.1084/jem.20061196

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Published: Mar 29, 2009
Vol/Issue: 15(4)
Pages: 410-416
License: View

Authors

H

HAMIDA HAMMAD

Unité de la Institute National de la Santé et de Recherche Medicale U 416, Institut Pasteur de Lille and Clinique des Maladies Respiratoires, Centre Hopitalier de Recherche Universitaire, Lille, France; Division des Soins Intensifs de Médecine, University Hospital, Geneva, Switzerland

Cite This Article

HAMIDA HAMMAD, Marcello Chieppa, Frederic Perros, et al. (2009). House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nature Medicine, 15(4), 410-416. https://doi.org/10.1038/nm.1946

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

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