The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

Youyou Tu

doi:10.1038/nm.2471

journal article Oct 01, 2011

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

Youyou Tu

Nature Medicine Vol. 17 No. 10 pp. 1217-1220 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nm.2471

Topics

No keywords indexed for this article. Browse by subject →

References

46

[1]

Goldstein, J.L. Creation and revelation: two different routes to advancement in the biomedical sciences. Nat. Med. 13, 1151–1154 (2007). 10.1038/nm1642

[2]

Collaboration Research Group for Qinghaosu. A new sesquiterpene lactone—qinghaosu [in Chinese]. Kexue Tongbao 3, 142 (1977).

[3]

Liu, J.M. et al. Structure and reaction of qinghaosu [in Chinese]. Acta Chimi. Sin. 37, 129–143 (1979).

[4]

Collaboration research group for Qinghaosu. Studies on new anti-malarial drug qinghaosu [in Chinese]. Yaoxue Tongbao 14, 49–53 (1979).

[5]

Collaboration research group for Qinghaosu. Antimalarial studies on qinghaosu [in Chinese]. Chin. Med. J. 92, 811–816 (1979).

[6]

Tu, Y.Y. The awarded Chinese invention: antimalarial drug qinghaosu [in Chinese]. Rev. World Invent. 4, 26 (1981).

[7]

Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L [in Chinese]. Yao Xue Xue Bao 16, 366–370 (1981).

[8]

Tu, Y.Y., Ni, M.Y., Zhong, Y.R. & Li, L.N. Studies on the constituents of Artemisia annua L. and derivatives of artemisinin [in Chinese]. Zhongguo Zhong Yao Za Zhi 6, 31 (1981).

[9]

Tu, Y.Y. et al. Studies on the constituents of Artemisia annua L. (II). Planta Med. 44, 143–145 (1982). 10.1055/s-2007-971424

[10]

Collaboration Research Group for Qinghaosu. Chemical studies on qinghaosu. J. Tradit. Chin. Med. 2, 3–8 (1982).

[11]

Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Yao Xue Xue Bao 19, 909–913 (1984).

[12]

Tu, Y.Y., Yin, J.P., Ji, L., Huang, M.M. & Liang, X.T. Studies on the constituents of Artemisia annua L. (III) [in Chinese]. Chin. Tradit. Herbal Drugs 16, 200–201 (1985).

[13]

Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia apiacea Hance [in Chinese]. Chin. Tradit. Herbal Drugs 6, 2–3 (1985).

[14]

Tu, Y.Y., Zhu, Q.C. & Shen, X. Studies on the constituents of Young Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 10, 419–420 (1985).

[15]

Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia gmelinii Web.exstechm [in Chinese]. Chin. Bull. Bot. 3, 34–37 (1985).

[16]

Wu, C.M. & Tu, Y.Y. Studies on the constituents of Artemisia argyi Levl et vant [in Chinese]. Zhongguo Zhong Yao Za Zhi. 10, 31–32 (1985).

[17]

Xiao, Y.Q. & Tu, Y.Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore [in Chinese]. Acta Bot. Sin. 28, 307–310 (1986).

[18]

Tu, Y.Y. Study on authentic species of Chinese herbal drug winghao [in Chinese]. Bull. Chin. Mater. Med. 12, 2–5 (1987).

[19]

Yin, J.P. & Tu, Y.Y. Studies on the constituents of Artemisia eriopoda Bunge [in Chinese]. Chin. Tradit. Herbal Drugs 20, 149–150 (1989).

[20]

Gu, Y.C. & Tu, Y.Y. Studies on chemical constituents of Artemisia japonica Thunb [in Chinese]. Chin. Tradit. Herbal Drugs 24, 122–124 (1993).

[21]

Klayman, D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049–1055 (1985). 10.1126/science.3887571

[22]

Sun, X.Z. et al. Experimental study on the immunosuppressive effects of qinghaosu and its derivatives [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 11, 37–38 (1993).

[23]

Yang, S.X., Xie, S.S., Ma, D., Long, Z.Z. & Tu, Y.Y. Immunologic enhancement and reconstitution by qinghaosu and its derivatives [in Chinese]. Chin. Bull. Pharm 9, 61–63 (1992).

[24]

Chen, P.H., Tu, Y.Y., Wang, F.Y., Li, F.W. & Yang, L. Effect of dihydroqinghaosu on the development of Plasmodium yoelii in Anopheles stephensi [in Chinese]. Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 16, 421–424 (1998).

[25]

Huang, L. et al. Studies on the antipyretic and anti-inflammatory effects of Artemisia annua L [in Chinese]. Zhongguo Zhong Yao Za Zhi 18, 44–48 (1993).

[26]

Tu, Y.Y. The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu. Chin. Med. J. 112, 976–977 (1999).

[27]

Xu, L.M., Chen, X.R. & Tu, Y.Y. Effect of hydroartemisinin on lupus BXSB mice [in Chinese]. Chin. J. Dermatovenerol. Integr. Tradit. West. Med. 1, 19–20 (2002).

[28]

Dong, Y.J. et al. Effect of dihydro-qinghaosu on auto-antibody production, TNFa secretion and pathologic change of lupus nephritis in BXSB mice [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 23, 676–679 (2003).

[29]

Dong, Y.J. et al. The effects of DQHS on the pathologic changes in BXSB mice lupus nephritis and the effect mechanism [in Chinese]. Chin. Pharmacol. Bull. 19, 1125–1128 (2003).

[30]

Tu, Y.Y. The development of the antimalarial drugs with new type of chemical structure—qinghaosu and dihydroqinghaosu. Southeast Asian J. Trop. Med. Public Health 35, 250–251 (2004).

[31]

Yang, L., Huang, M.M., Zhang, D. & Tu, Y.Y. Determination of scopoletin in qinghao by HPLC [in Chinese]. Chin. J. Exp. Tradit. Med. Formulae 12, 10–11 (2006).

[32]

Li, W.D., Dong, Y.J., Tu, Y.Y. & Lin, Z.B. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int. Immunopharmacol. 6, 1243–1250 (2006). 10.1016/j.intimp.2006.03.004

[33]

Zhang, D., Yang, L., Yang, L.X., Huang, M.M. & Tu, Y.Y. Determination of artemisinin, arteannuin B and artemisinic acid in Artemisia annua by HPLC-UV-ELSD [in Chinese]. Yao Xue Xue Bao 42, 978–981 (2007).

[34]

Qinghao Ji Qinghaosulei Yaowu (Artemisia annua L., Artemisinin and its Derivatives) [in Chinese] (ed. Tu, Y.Y.) (Publisher of Chemical Industry, Beijing, 2009).

[35]

Chen, G.Q. et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 89, 3345–3353 (1997).

[36]

Zhang, X.W. et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 328, 240–243 (2010). 10.1126/science.1183424

[37]

Tang, X.C. & Han, Y.F. Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb. CNS Drug Rev. 5, 281–300 (1999). 10.1111/j.1527-3458.1999.tb00105.x

[38]

Chen, K.J. et al. XS0601 reduces the incidence of restenosis: a prospective study of 335 patients undergoing percutaneous coronary intervention in China. Chin. Med. J. 119, 6–13 (2006). 10.1097/00029330-200601010-00002

[39]

Gao, D. et al. The effect of Xuefu Zhuyu decoction on in vitro endothelial progenitor cell tube formation. Chin. J. Integr. Med. 16, 50–53 (2010). 10.1007/s11655-010-0050-y

[40]

Zhao, N. et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am. J. Physiol. Heart Circ. Physiol. 298, H1166–H11176 (2010). 10.1152/ajpheart.01186.2009

[41]

Xu, X.S. et al. The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock 32, 201–209 (2009). 10.1097/shk.0b013e3181971f47

[42]

Sun, K. et al. Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia–reperfusion. J. Ethnopharmacol. 130, 398–406 (2010). 10.1016/j.jep.2010.05.030

[43]

Han, J.Y. et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Ther. 117, 280–295 (2008). 10.1016/j.pharmthera.2007.09.008

[44]

Liao, F. et al. Biomechanopharmacology: a new borderline discipline. Trends Pharmacol. Sci. 27, 287–289 (2006). 10.1016/j.tips.2006.04.001

[45]

You, Y. et al. Joint preventive effects of swimming and Shenlian extract on rat atherosclerosis. Clin. Hemorheol. Microcirc. 47, 187–198 (2011). 10.3233/ch-2010-1380

[46]

Xie, L.X. et al. The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. Clin. Hemorheol. Microcirc. 44, 245–258 (2010). 10.3233/ch-2010-1269

Cited By

1,178

Artesunate protects against ischemic stroke through THBS2/CD36/TLR4 pathway

Shanshan Luo, Bilu Li · 2026

International Immunopharmacology

Plant defense-directed discovery of a natural anti-psoriasis agent targeting GAPDH

Tianjun Zhou, Yu Zheng · 2025

Science Advances

Traditional Chinese medicine for sepsis: advancing from evidence to innovative drug discovery

Yun Ji, Hongyun Song · 2025

Critical Care

Development and challenges of mass spectrometry database for traditional Chinese medicine: A review

Yijun Wang, Zhiming Yang · 2025

Science of Traditional Chinese Medi...

Natural products in antiparasitic drug discovery: advances, opportunities and challenges

Xiaofei Shang, Lixia Dai · 2025

Natural Product Reports

Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Yang Liu, Jing-Jing Jiang · 2024

Science

Artemisinin optimization based on malaria therapy: Algorithm and applications to medical image segmentation

Chong Yuan, Dong Zhao · 2024

Displays

Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa

Philip J. Rosenthal, Victor Asua · 2024

Nature Reviews Microbiology

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK

Li Yuan-Ce, Zhang Qi · 2023

Frontiers in Pharmacology

An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Monika Shukla, Komal Rathi · 2023

Medicinal Research Reviews

The Effect of Epimedium Isopentenyl Flavonoids on the Broiler Gut Health Using Microbiomic and Metabolomic Analyses

Jiaqi Zhang, Qingyu Zhao · 2023

International Journal of Molecular...

Application and Development of Natural Plant Metabolite Oleanolic Acid in the Nano Era

Kun Wang, Qinyue Lu · 2022

Agriculture

Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

Wenqian Huang, Yingxia Wang · 2022

Antibiotics

Lepidopteran mevalonate pathway optimization in Escherichia coli efficiently produces isoprenol analogs for next-generation biofuels

Bo Pang, Jia Li · 2021

Metabolic Engineering

Tapping into non-English-language science for the conservation of global biodiversity

Tatsuya Amano, Violeta Berdejo-Espinola · 2021

PLOS Biology

Material-herbology: An effective and safe strategy to eradicate lethal viral-bacterial pneumonia

Jun Li, Ziao Zhou · 2021

Matter

A Carbohydrate‐based Synthetic Approach to Diverse Structurally and Stereochemically Complex Chiral Polyheterocycles

Samuzal Bhuyan, Dharmendra Das · 2021

Chemistry – An Asian Journal

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

Euna Yoo, Christopher J. Schulze · 2020

Cell Chemical Biology

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

Xueke Shi, Christian D. Young · 2020

Biomolecules

NPBS database: a chemical data resource with relational data between natural products and biological sources

Tingjun Xu, Weiming Chen · 2020

Database

Metrics

1,178

Citations

46

References

Details

Published: Oct 01, 2011
Vol/Issue: 17(10)
Pages: 1217-1220
License: View

Authors

Y

Youyou Tu

Cite This Article

Youyou Tu (2011). The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Medicine, 17(10), 1217-1220. https://doi.org/10.1038/nm.2471

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

You May Also Like