Anatomy and regulation of the central melanocortin system

Roger D Cone

doi:10.1038/nn1455

journal article Apr 26, 2005

Anatomy and regulation of the central melanocortin system

Roger D Cone

Nature Neuroscience Vol. 8 No. 5 pp. 571-578 · Springer Science and Business Media LLC

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References

100

[1]

Haskell-Luevano, C. et al. Characterization of the neuroanatomical distribution of agouti-related protein (AGRP) immunoreactivity in the rhesus monkey and the rat. Endocrinology 140, 1408–1415 (1999). 10.1210/endo.140.3.6544

[2]

Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131–141 (1997). 10.1016/s0092-8674(00)81865-6

[3]

Yen, T.T., Gill, A.M., Frigeri, L.G., Barsh, G.S. & Wolff, G.L. Obesity, diabetes, and neoplasia in yellow Avy/− mice: ectopic expression of the agouti gene. FASEB J. 8, 479–488 (1994). 10.1096/fasebj.8.8.8181666

[4]

Butler, A.A. et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518–3521 (2000). 10.1210/endo.141.9.7791

[5]

Yaswen, L., Diehl, N., Brennan, M.B. & Hochgeschwender, U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066–1070 (1999). 10.1038/12506

[6]

Ollmann, M.M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135–137 (1997). 10.1126/science.278.5335.135

[7]

Krude, H. et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155–157 (1998). 10.1038/509

[8]

Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat. Genet. 20, 113–114 (1998). 10.1038/2407

[9]

Yeo, G.S.H. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20, 111–112 (1998). 10.1038/2404

[10]

Farooqi, I.S. et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J. Clin. Invest. 106, 271–279 (2000). 10.1172/jci9397

[11]

Vaisse, C. et al. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106, 253–262 (2000). 10.1172/jci9238

[12]

Farooqi, I.S. et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348, 1160–1163 (2003). 10.1056/nejmoa022050

[13]

Branson, R. et al. Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N. Engl. J. Med. 348, 1096–1103 (2003). 10.1056/nejmoa021971

[14]

Butler, A.A. et al. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat. Neurosci. 4, 605–611 (2001). 10.1038/88423

[15]

Fan, W. et al. The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141, 3072–3079 (2000). 10.1210/endo.141.9.7665

[16]

Watson, S.J., Akil, H., Richard, C.W. & Barchas, J.D. Evidence for two separate opiate peptide neuronal systems and the coexistence of β-lipotropin, β-endorphin, and ACTH immunoreactivities in the same hypothalamic neurons. Nature 275, 226–228 (1978). 10.1038/275226a0

[17]

Jacobowitz, D.M. & O'Donohue, T.L. α-Melanocyte-stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Proc. Natl. Acad. Sci. USA 75, 6300–6304 (1978). 10.1073/pnas.75.12.6300

[18]

Nilaver, G. et al. Adrenocorticotropin and beta-lipotropin in the hypothalamus. Localization in the same arcuate neurons by sequential immunocytochemical procedures. J. Cell Biol. 81, 50–58 (1979). 10.1083/jcb.81.1.50

[19]

Joseph, S.A. & Michael, G.J. Efferent ACTH-IR opiocortin projections from nucleus tractus solitarius: a hypothalamic deafferentation study. Peptides 9, 193–201 (1988). 10.1016/0196-9781(88)90027-7

[20]

Pilcher, W.H. & Joseph, S.A. Differential sensitivity of hypothalamic and medullary opiocortin and tyrosine hydroxylase neurons to the neurotoxic effects of monosodium glutamate (MSG). Peptides 7, 783–789 (1986). 10.1016/0196-9781(86)90096-3

[21]

Hentges, S.T. et al. GABA release from POMC neurons. J. Neurosci. 24, 1578–1583 (2004). 10.1523/jneurosci.3952-03.2004

[22]

Collin, M. et al., Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur. J. Neurosci. 18, 1265–1278 (2003). 10.1046/j.1460-9568.2003.02840.x

[23]

Broberger, C., Johansen, J., Johansson, C., Schalling, M. & Hokfelt, T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA 95, 15043–15048 (1998). 10.1073/pnas.95.25.15043

[24]

Hakansson, M.L., Hulting, A.L. & Meister, B. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus—relationship with NPY neurones. Neuroreport 7, 3087–3092 (1996). 10.1097/00001756-199611250-00059

[25]

Elmquist, J.K., Ahima, R.S., Maratos-Flier, E., Flier, J.S. & Saper, C.B. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138, 839–842 (1997). 10.1210/endo.138.2.5033

[26]

Stephens, T. et al. The role of neuropeptide Y in the antiobesity action of the obesity gene product. Nature 377, 530–532 (1995). 10.1038/377530a0

[27]

Erickson, J., Hollopeter, G. & Palmiter, J.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704–1707 (1996). 10.1126/science.274.5293.1704

[28]

Mizuno, T.M. & Mobbs, C.V. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140, 814–817 (1999). 10.1210/endo.140.2.6491

[29]

Mizuno, T.M. et al. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and corrected in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47, 294–297 (1998). 10.2337/diab.47.2.294

[30]

Schwartz, M.W. et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119–2123 (1997). 10.2337/diab.46.12.2119

[31]

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

Kevin D. Niswender, Denis G. Baskin, Michael W. Schwartz

Trends in Endocrinology & Metabolism 2004 10.1016/j.tem.2004.07.009

[32]

Spanswick, D., Smith, M.A., Mirshamsi, S., Routh, V.H. & Ashford, M.L. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat. Neurosci. 3, 757–758 (2000). 10.1038/77660

[33]

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Jens C. Brüning, Dinesh Gautam, Deborah J. Burks et al.

Science 2000 10.1126/science.289.5487.2122

[34]

Obici, S., Zhang, B.B., Karkanias, G. & Rossetti, L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8, 1376–1382 (2002). 10.1038/nm1202-798

[35]

Blum, M., Roberts, J.L. & Wardlaw, S.L. Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology 124, 2283–2288 (1989). 10.1210/endo-124-5-2283

[36]

Kelly, M.J., Qiu, J. & Ronnekleiv, O.K. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. Ann. NY Acad. Sci. 1007, 6–16 (2003). 10.1196/annals.1286.001

[37]

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Michael A. Cowley, James L. Smart, Marcelo Rubinstein et al.

Nature 2001 10.1038/35078085

[38]

Cowley, M.A. et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37, 649–661 (2003). 10.1016/s0896-6273(03)00063-1

[39]

Heisler, L.K. et al. Activation of central melanocortin pathways by fenfluramine. Science 297, 609–611 (2002). 10.1126/science.1072327

[40]

Roseberry, A.G., Liu, H., Jackson, A.C., Cai, X. & Friedman, J.M. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41, 711–722 (2004). 10.1016/s0896-6273(04)00074-1

[41]

Ibrahim, N. et al. Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 144, 1331–1340 (2003). 10.1210/en.2002-221033

[42]

Takahashi, K.A. & Cone, R.D. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 146, 1043–1047 (2005). 10.1210/en.2004-1397

[43]

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Masayasu Kojima, Hiroshi Hosoda, Yukari Date et al.

Nature 1999 10.1038/45230

[44]

Kojima, M., Hosoda, H., Matsuo, H. & Kangawa, K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol. Metab. 12, 118–122 (2001). 10.1016/s1043-2760(00)00362-3

[45]

Ariyasu, H. et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 86, 4753–4758 (2001). 10.1210/jcem.86.10.7885

[46]

Tschop, M. et al. Post-prandial decrease of circulating human ghrelin levels. J. Endocrinol. Invest. 24, RC19–RC21 (2001). 10.1007/bf03351037

[47]

Cummings, D.E. et al. A preprandial rise in plasma ghrelin levels suggest a role in meal initiation in humans. Diabetes 50, 1714–1719 (2001). 10.2337/diabetes.50.8.1714

[48]

Tschop, M., Smiley, D.L. & Heiman, M.L. Ghrelin induces adiposity in rodents. Nature 407, 908–913 (2000). 10.1038/35038090

[49]

Willesen, M., Kristensen, P. & Romer, J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70, 306–316 (1999). 10.1159/000054491

[50]

Hewson, A.K. & Dickson, S.L. Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J. Neuroendocrinol. 12, 1047–1049 (2000). 10.1046/j.1365-2826.2000.00584.x

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