Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides

Koji Kubota; Tetsu Makino; Keisuke Kondo; Tamae Seo; Mingoo Jin; Hajime Ito

doi:10.1039/d4gc06362g

journal article Open Access Jan 01, 2025

Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides

Koji Kubota

Tetsu Makino Keisuke Kondo Tamae Seo Mingoo Jin

Hajime Ito

Green Chem. Vol. 27 No. 6 pp. 1771-1776 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d4gc06362g

Abstract

A simple mechanochemical protocol for solid-state aromatic nucleophilic fluorination using potassium fluoride (KF) and quaternary ammonium salts was developed.

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Details

Published: Jan 01, 2025
Vol/Issue: 27(6)
Pages: 1771-1776
License: View

Authors

K

Koji Kubota

Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido, Japan

T

Tetsu Makino

Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan

K

Keisuke Kondo

Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan

T

Tamae Seo

Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan

M

Mingoo Jin

Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido, Japan

H

Hajime Ito

Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido, Japan

Funding

Japan Society for the Promotion of Science Award: 24H00453

Cite This Article

Koji Kubota, Tetsu Makino, Keisuke Kondo, et al. (2025). Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides. Green Chem., 27(6), 1771-1776. https://doi.org/10.1039/d4gc06362g

Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides

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