Multifunctionality of Prostatic Acid Phosphatase in Prostate  Cancer Pathogenesis

Evgenia Alpert; Armin Akhavan; Arie Gruzman; William J Hansen; Joshua Lehrer- Graiwer; Steven C Hall; Eric Johansen; Sean McAllister; Mittul Gulati; Ming-Fong Lin; Vishwanath R Lingappa

doi:10.1042/bcj20200944

journal article Open Access Oct 04, 2021

Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis

Arie Gruzman William J Hansen Joshua Lehrer- Graiwer Steven C Hall Eric Johansen Sean McAllister Mittul Gulati Ming-Fong Lin Vishwanath R Lingappa

Bioscience Reports · Portland Press Ltd.

View at Publisher Save 10.1042/bcj20200944

Abstract

The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomic tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal sequence of secretory/membrane proteins with corresponding regions of functionally distinct signal sequence subtypes). This manipulation preferentially redirects proteins to different pathways of biogenesis at the endoplasmic reticulum, magnifying normally difficult to detect subsets of the protein of interest. For PAcP this technique reveals three forms identical in amino acid sequence but profoundly different in physiological functions, subcellular location, and biochemical properties. These three forms of PAcP can also occur with the wild-type PAcP signal sequence. Clinical specimens from patients with prostate cancer demonstrate that one form, termed PLPAcP, correlates with early prostate cancer. These findings confirm the analytical power of this method, implicate PLPAcP in prostate cancer pathogenesis, and suggest novel anticancer therapeutic strategies.

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Published: Oct 04, 2021
License: View

Authors

E

Evgenia Alpert

Bioconformatics laboratory of the California Pacific Medical Center (CPMC) Research Institute, Ramat-Gan, California, United States

A

Armin Akhavan

Bioconformatics Laboratory of the California Pacific Medical Center (CPMC) Research Institute, San Francisco, California, United States

A

Arie Gruzman

Bioconformatics Laboratory of the California Pacific Medical Center (CPMC) Research Institute, San Francisco, California, United States

W

William J Hansen

Prosetta Corporation, San Francisco, California, United States

J

Joshua Lehrer- Graiwer

Bioconformatics Laboratory of the California Pacific Medical Center (CPMC) Research Institute, San Francisco, California, United States

S

Steven C Hall

UCSF, San Francisco, California, United States

E

Eric Johansen

UCSF, San Francisco, California, United States

S

Sean McAllister

Cancer Laboratory of the California Pacific Medical Center (CPMC) Research Institute, San Francisco, California, United States

M

Mittul Gulati

UCSF, San Francisco, California, United States

M

Ming-Fong Lin

University of Nebraska Medical Center, Omaha, Nebraska, United States

V

Vishwanath R Lingappa

Bioconformatics Laboratory of the California Pacific Medical Center (CPMC) Research Institute, San Francisco, California, United States

Cite This Article

Evgenia Alpert, Armin Akhavan, Arie Gruzman, et al. (2021). Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis. Bioscience Reports. https://doi.org/10.1042/bcj20200944

Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis

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