journal article
Open Access
Nov 21, 2018
Composition, structure and function of the eukaryotic flagellum distal tip
Abstract
Cilia and flagella are long extensions commonly found on the surface of eukaryotic cells. In fact, most human cells have a flagellum, and failure to correctly form cilia leads to a spectrum of diseases gathered under the name ‘ciliopathies’. The cilium distal tip is where it grows and signals. Yet, out of the flagellar regions, the distal tip is probably the least intensively studied. In this review, we will summarise the current knowledge on the diverse flagellar tip structures, the dynamicity and signalling that occurs here and the proteins localising to this important cellular region.
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Details
- Published
- Nov 21, 2018
- Vol/Issue
- 62(6)
- Pages
- 815-828
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Cite This Article
Jacob T. Croft, Davide Zabeo, Radhika Subramanian, et al. (2018). Composition, structure and function of the eukaryotic flagellum distal tip. Essays in Biochemistry, 62(6), 815-828. https://doi.org/10.1042/ebc20180032
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