Expression of fibroblast growth factor receptors during development and regression of the bovine corpus luteum

D. M. Guerra; I. C. Giometti; C. A. Price; P. B. Andrade; A. C. Castilho; M. F. Machado; P. Ripamonte; P. C. Papa; J. Buratini

doi:10.1071/rd07114

journal article Jul 09, 2008

Expression of fibroblast growth factor receptors during development and regression of the bovine corpus luteum

D. M. Guerra I. C. Giometti C. A. Price P. B. Andrade A. C. Castilho M. F. Machado P. Ripamonte P. C. Papa J. Buratini

Reproduction, Fertility and Development Vol. 20 No. 6 pp. 659-664 · CSIRO Publishing

View at Publisher Save 10.1071/rd07114

Abstract

There is evidence that fibroblast growth factors (FGFs) are involved in the regulation of growth and regression of the corpus luteum (CL). However, the expression pattern of most FGF receptors (FGFRs) during CL lifespan is still unknown. The objective of the present study was to determine the pattern of expression of ‘B’ and ‘C’ splice variants of FGFRs in the bovine CL. Bovine CL were collected from an abattoir and classed as corpora hemorrhagica (Stage I), developing (Stage II), developed (Stage III) or regressed (Stage IV) CL. Expression of FGFR mRNA was measured by semiquantitative reverse transcription-polymerase chain reaction and FGFR protein was localised by immunohistochemistry. Expression of mRNA encoding the ‘B’ and ‘C’ spliced forms of FGFR1 and FGFR2 was readily detectable in the bovine CL and was accompanied by protein localisation. FGFR1C and FGFR2C mRNA expression did not vary throughout CL lifespan, whereas FGFR1B was upregulated in the developed (Stage III) CL. FGFR3B, FGFR3C and FGFR4 expression was inconsistent in the bovine CL. The present data indicate that FGFR1 and FGFR2 splice variants are the main receptors for FGF action in the bovine CL.

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Details

Published: Jul 09, 2008
Vol/Issue: 20(6)
Pages: 659-664
License: View

Authors

D

D. M. Guerra

ADepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.

I

I. C. Giometti

BDepartamento de Reprodução Animal e Radiologia Veterinária, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.

C

C. A. Price

CCentre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, Quebec, Canada.

P

P. B. Andrade

ADepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.

A

A. C. Castilho

DDepartamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.

M

M. F. Machado

CCentre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, Quebec, Canada.

P

P. Ripamonte

ADepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.

P

P. C. Papa

EDepartamento de Cirurgia, Setor de Anatomia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brasil.

J

J. Buratini

ADepartamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo, Brasil.; FCorresponding author. Email: buratini@ibb.unesp.br

Cite This Article

D. M. Guerra, I. C. Giometti, C. A. Price, et al. (2008). Expression of fibroblast growth factor receptors during development and regression of the bovine corpus luteum. Reproduction, Fertility and Development, 20(6), 659-664. https://doi.org/10.1071/rd07114

Expression of fibroblast growth factor receptors during development and regression of the bovine corpus luteum

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