journal article Feb 01, 1989

The scanning model for translation: an update.

The Journal of cell biology Vol. 108 No. 2 pp. 229-241 · Rockefeller University Press

View at Publisher Save 10.1083/jcb.108.2.229

Abstract

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.

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Details

Published: Feb 01, 1989
Vol/Issue: 108(2)
Pages: 229-241

Authors

Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.

Cite This Article

M Kozak (1989). The scanning model for translation: an update.. The Journal of cell biology, 108(2), 229-241. https://doi.org/10.1083/jcb.108.2.229

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