Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek Narendra; Atsushi Tanaka; Der-Fen Suen; Richard J. Youle

doi:10.1083/jcb.200809125

journal article Nov 24, 2008

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek Narendra Atsushi Tanaka

Der-Fen Suen Richard J. Youle

The Journal of cell biology Vol. 183 No. 5 pp. 795-803 · Rockefeller University Press

View at Publisher Save 10.1083/jcb.200809125

Abstract

Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron maintenance is unknown, recent work has linked Parkin to the regulation of mitochondria. Its loss is associated with swollen mitochondria and muscle degeneration in Drosophila melanogaster, as well as mitochondrial dysfunction and increased susceptibility to mitochondrial toxins in other species. Here, we show that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential in mammalian cells. After recruitment, Parkin mediates the engulfment of mitochondria by autophagosomes and the selective elimination of impaired mitochondria. These results show that Parkin promotes autophagy of damaged mitochondria and implicate a failure to eliminate dysfunctional mitochondria in the pathogenesis of Parkinson's disease.

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Details

Published: Nov 24, 2008
Vol/Issue: 183(5)
Pages: 795-803

Authors

D

Derek Narendra

1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; 2Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814

A

Atsushi Tanaka

1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

D

Der-Fen Suen

1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

R

Richard J. Youle

1Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

Cite This Article

Derek Narendra, Atsushi Tanaka, Der-Fen Suen, et al. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. The Journal of cell biology, 183(5), 795-803. https://doi.org/10.1083/jcb.200809125

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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