Autophagy in airway diseases: a new frontier in human asthma?

A. A. Zeki; B. Yeganeh; N. J. Kenyon; M. Post; S. Ghavami

doi:10.1111/all.12761

journal article Oct 20, 2015

Autophagy in airway diseases: a new frontier in human asthma?

A. A. Zeki B. Yeganeh N. J. Kenyon M. Post S. Ghavami

Allergy Vol. 71 No. 1 pp. 5-14 · Wiley

View at Publisher Save 10.1111/all.12761

Abstract

AbstractThe study of autophagy (‘self‐eating’), a fundamental cell fate pathway involved in physiological and pathological subcellular processes, opens a new frontier in the continuous search for novel therapies for human asthma. Asthma is a complex syndrome with different disease phenotypes. Autophagy plays a central role in cell physiology, energy and metabolism, and cell survival. Autophagy's hallmark is the formation of double‐membrane autophagic autophagosomes, and this process is operational in airway epithelial and mesenchymal cells in asthma. Genetic associations between autophagy genes and asthma have been observed including single nucleotide polymorphisms in Atg5 which correlate with reduced lung function. Immune mechanisms important in asthma such as Th2 cells and eosinophils also manifest autophagy. Lastly, we address the role of autophagy in extracellular matrix deposition and fibrosis in asthmatic airways remodeling, a pathologic process still without effective therapy, and discuss potential pharmacologic inhibitors. We end by offering two opposing but plausible hypotheses as to how autophagy may be directly involved in airway fibrosis.

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References

Details

Published: Oct 20, 2015
Vol/Issue: 71(1)
Pages: 5-14
License: View

Authors

A

A. A. Zeki

Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine Center for Comparative Respiratory Biology and Medicine Davis CA USA

B

B. Yeganeh

Physiology and Experimental Medicine Hospital for Sick Children (Sickkids) University of Toronto Toronto ON Canada

N

N. J. Kenyon

Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine Center for Comparative Respiratory Biology and Medicine Davis CA USA

M

M. Post

Physiology and Experimental Medicine Hospital for Sick Children (Sickkids) University of Toronto Toronto ON Canada

S

S. Ghavami

Department of Human Anatomy & Cell Science Faculty of Health Sciences College of Medicine University of Manitoba Winnipeg MB Canada

Funding

Manitoba Medical Services Foundation

Cite This Article

A. A. Zeki, B. Yeganeh, N. J. Kenyon, et al. (2015). Autophagy in airway diseases: a new frontier in human asthma?. Allergy, 71(1), 5-14. https://doi.org/10.1111/all.12761

Autophagy in airway diseases: a new frontier in human asthma?

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