T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

G. Varricchi; J. Harker; F. Borriello; G. Marone; S. R. DURHAM; M. H. Shamji

doi:10.1111/all.12878

journal article May 25, 2016

T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

G. Varricchi J. Harker F. Borriello G. Marone S. R. DURHAM M. H. Shamji

Allergy Vol. 71 No. 8 pp. 1086-1094 · Wiley

View at Publisher Save 10.1111/all.12878

Abstract

AbstractFollicular helper T cells (Tfh) are located within germinal centers of lymph nodes. Cognate interaction between Tfh, B cells, and IL‐21 drives B cells to proliferate and differentiate into plasma cells thereby leading to antibody production. Tfh cells and IL‐21 are involved in infectious and autoimmune diseases, immunodeficiencies, vaccination, and cancer. Human peripheral blood CXCR5+ CD4+ T cells comprise different subsets of Tfh‐like cells. Despite the importance of the IgE response in the pathogenesis of allergic disorders, little is known about the role of follicular and blood Tfh cells and IL‐21 in human and experimental allergic disease. Here, we review recent advances regarding the phenotypic and functional characteristics of both follicular and blood Tfh cells and of the IL‐21/IL‐21R system in the context of allergic disorders.

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References

Details

Published: May 25, 2016
Vol/Issue: 71(8)
Pages: 1086-1094
License: View

Authors

G

G. Varricchi

Immunomodulation and Tolerance Group Imperial College London London UK; Allergy and Clinical Immunology Imperial College London London UK

J

J. Harker

Inflammation, Repair & Development Section Faculty of Medicine National Heart and Lung Institute Imperial College London London UK; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma London UK

F

F. Borriello

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI) School of Medicine University of Naples Federico II Naples Italy

G

G. Marone

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI) School of Medicine University of Naples Federico II Naples Italy; CNR Institute of Experimental Endocrinology and Oncology ‘G. Salvatore’ Naples Italy

S

S. R. DURHAM

Immunomodulation and Tolerance Group Imperial College London London UK; Allergy and Clinical Immunology Imperial College London London UK

M

M. H. Shamji

Immunomodulation and Tolerance Group Imperial College London London UK; Allergy and Clinical Immunology Imperial College London London UK

Funding

Ministero dell’Istruzione, dell’Università e della Ricerca

Regione Campania

Cite This Article

G. Varricchi, J. Harker, F. Borriello, et al. (2016). T follicular helper (Tfh) cells in normal immune responses and in allergic disorders. Allergy, 71(8), 1086-1094. https://doi.org/10.1111/all.12878

T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

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