The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years

Sophie Nicklaus; Amandine Divaret‐Chauveau; Marie‐Laure Chardon; Caroline Roduit; Vincent Kaulek; Eléa Ksiazek; Marie‐Laure Dalphin; Anne M. Karvonen; Pirkka Kirjavainen; Juha Pekkanen; Roger Lauener; Elisabeth Schmausser‐Hechfellner; Harald Renz; Charlotte Braun‐Fahrländer; Josef Riedler; Dominique A. Vuitton; Erika von Mutius; Jean‐Charles Dalphin

doi:10.1111/all.13650

journal article Nov 19, 2018

The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years

Sophie Nicklaus

Amandine Divaret‐Chauveau

Marie‐Laure Chardon Caroline Roduit

Vincent Kaulek Eléa Ksiazek Marie‐Laure Dalphin Anne M. Karvonen

Pirkka Kirjavainen Juha Pekkanen

Roger Lauener Elisabeth Schmausser‐Hechfellner Harald Renz

Charlotte Braun‐Fahrländer Josef Riedler Dominique A. Vuitton Erika von Mutius

Jean‐Charles Dalphin

Allergy Vol. 74 No. 4 pp. 788-798 · Wiley

View at Publisher Save 10.1111/all.13650

Abstract

AbstractBackgroundThe effect of exposure to microorganisms on allergic diseases has been well studied. The protective effect of early food diversity against allergic diseases was previously shown in the PASTURE cohort study. The consumption of cheese, a food potentially rich in microbial diversity, deserves further examination. We aimed to evaluate whether cheese consumption is associated with allergic diseases.MethodsIn the PASTURE study (birth cohort in 5 European countries), data on feeding practices, environmental factors, and allergic diseases were collected by questionnaires from birth to 6 years (N = 931). Cheese consumption at 18 months of age was quantified in terms of frequency and diversity (ie, number of consumed types among 6 types: hard pressed, semipressed, soft, blue, fresh cheese, and cheese from the farm). Multiple logistic regressions were performed to evaluate the effect of cheese consumption on atopic dermatitis (AD), food allergy (FA), allergic rhinitis, asthma, and atopic sensitization at 6 years after adjustment for confounders of atopy.ResultsCheese consumption (vs. nonconsumption) had a significant protective effect on AD (OR = 0.51 [0.29‐0.90], P = 0.02) and FA (OR = 0.32, [0.15‐0.71], P = 0.004), but no effect on atopic sensitization, allergic rhinitis, and asthma at 6 years. This effect on AD and FA may be related to the diversity of consumed cheeses (OR = 0.64 [0.48‐0.85] per cheese type, P = 0.002; OR = 0.55 [0.33‐0.92], P = 0.02, respectively).ConclusionAlthough reverse causality cannot totally be ruled out, cheese diversity at 18 months had a protective effect against AD and FA at 6 years in addition to the protective effect of diversity of other foods.

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Details

Published: Nov 19, 2018
Vol/Issue: 74(4)
Pages: 788-798
License: View

Authors

S

Sophie Nicklaus

Centre des Sciences du Goût et de l'Alimentation AgroSup Dijon, CNRS INRA Université Bourgogne Franche‐Comté Dijon France

A

Amandine Divaret‐Chauveau

Pediatrics Department University Hospital of Besançon Besançon France; Pediatric Allergy Department University Hospital of Nancy Nancy France

M

Marie‐Laure Chardon

University Hospital of Besançon, Respiratory Disease Besançon France; Hospital of Haute‐Saône, Respiratory disease Vesoul France

C

Caroline Roduit

Christine Kühne Center for Allergy Research and Education (CK‐CARE) Davos Switzerland; Children's Hospital University of Zürich Zürich Switzerland

V

Vincent Kaulek

University Hospital of Besançon, Respiratory Disease UMR6249 ChronoEnvironnement CNRS and Université Bourgogne Franche‐Comté Besançon France

E

Eléa Ksiazek

Centre des Sciences du Goût et de l'Alimentation AgroSup Dijon, CNRS INRA Université Bourgogne Franche‐Comté Dijon France

M

Marie‐Laure Dalphin

University Hospital of Besançon, Respiratory Disease UMR6249 ChronoEnvironnement CNRS and Université Bourgogne Franche‐Comté Besançon France

A

Anne M. Karvonen

Department of Health Security National Institute for Health and Welfare Kuopio Finland

P

Pirkka Kirjavainen

Department of Health Security National Institute for Health and Welfare Kuopio Finland

J

Juha Pekkanen

Department of Health Security National Institute for Health and Welfare Kuopio Finland; Department of Public Health University of Helsinki Helsinki Finland

R

Roger Lauener

Christine Kühne Center for Allergy Research and Education (CK‐CARE) Davos Switzerland; Children's Hospital of Eastern Switzerland St. Gallen Switzerland

E

Elisabeth Schmausser‐Hechfellner

Dr. Von Hauner Children's Hospital Ludwig Maximilians University Munich Munich Germany

H

Harald Renz

Department of Clinical Chemistry and Molecular Diagnostics Philipps University of Marburg Marburg Germany

C

Charlotte Braun‐Fahrländer

Swiss Tropical and Public Health Institute Basel Switzerland; University of Basel Basel Switzerland

J

Josef Riedler

Children's Hospital Schwarzach Schwarzach Austria; Teaching Hospital of Paracelsus Medical Private University Salzburg Salzburg Austria

D

Dominique A. Vuitton

Université Bourgogne Franche‐Comté Besançon France

E

Erika von Mutius

Dr. Von Hauner Children's Hospital Ludwig Maximilians University Munich Munich Germany; Institute for Asthma and Allergy Prevention Helmholtz Centre Munich Neuherberg Germany; German Center for Lung Research Munich Germany

J

Jean‐Charles Dalphin

University Hospital of Besançon, Respiratory Disease UMR6249 ChronoEnvironnement CNRS and Université Bourgogne Franche‐Comté Besançon France

Cite This Article

Sophie Nicklaus, Amandine Divaret‐Chauveau, Marie‐Laure Chardon, et al. (2018). The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years. Allergy, 74(4), 788-798. https://doi.org/10.1111/all.13650

The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years

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