Synthetic hydrosilicate nanotubes induce low pro‐inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures

Tonje Skuland; Tatiana Maslennikova; Marit Låg; El´mira Gatina; Maria K. Serebryakova; Andrey S. Trulioff; Igor V. Kudryavtsev; Natalia Klebnikova; Irina Kruchinina; Per E. Schwarze; Magne Refsnes

doi:10.1111/bcpt.13341

journal article Nov 04, 2019

Synthetic hydrosilicate nanotubes induce low pro‐inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures

Tonje Skuland Tatiana Maslennikova Marit Låg El´mira Gatina Maria K. Serebryakova Andrey S. Trulioff Igor V. Kudryavtsev Natalia Klebnikova Irina Kruchinina Per E. Schwarze Magne Refsnes

Basic & Clinical Pharmacology & Toxicology Vol. 126 No. 4 pp. 374-388 · Wiley

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Abstract

AbstractAsbestos (Mg‐hydrosilicate; chrysotile) is known to cause pleural diseases, pulmonary fibrosis and lung cancers, via mechanisms strongly depending on diameter‐length ratio and possibly metal content. A critical question is whether synthetic hydrosilicate nanotubes (NTs) of short length possess little toxic potential compared to chrysotile. Five Mg‐ and two NiNTs of different lengths were assessed for cytotoxicity and pro‐inflammatory responses in THP‐1 macrophages and human bronchial epithelial lung cells (HBEC3‐KT), in comparison with chrysotile. NT lengths/diameters were characterized by TEM, surface areas by BET‐ and BJH analysis, and chemical composition by XRD. The different Mg‐ and NiNTs induced little cytotoxicity in both cell models, in contrast to chrysotile that induced marked cytotoxicity. The two longest synthetic MgNTs, with median lengths of 3 and 5 µm, induced increased levels of pro‐inflammatory cytokines in THP‐1 macrophages, but much less than chrysotile (median length 15 µm) and silica nanoparticles (Si10). The shortest NTs did not induce any increase in cytokines. In HBEC3‐KT cells, all synthetic NTs induced no or only small changes in cytokine responses, in contrast to chrysotile and Si10. The synthetic NTs induced lower TGF‐β responses than chrysotile in both cell models. In conclusion, the pro‐inflammatory responses were associated with the length of synthetic hydrosilicate NTs in THP‐1 macrophages, but not in HBEC3‐KT cells. Notably, the shortest NTs showed no or little pro‐inflammatory activity or cytotoxicity in both cell models. Such a safety by design approach is important for development of new materials being candidates for various new products.

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Metrics

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Citations

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References

Details

Published: Nov 04, 2019
Vol/Issue: 126(4)
Pages: 374-388
License: View

Authors

T

Tonje Skuland

Department of Air Pollution and Noise Norwegian Institute of Public Health Oslo Norway

T

Tatiana Maslennikova

Institute of Silicate Chemistry Russian Academy of Sciences St. Petersburg Russia

M

Marit Låg

Department of Air Pollution and Noise Norwegian Institute of Public Health Oslo Norway

E

El´mira Gatina

Institute of Silicate Chemistry Russian Academy of Sciences St. Petersburg Russia

M

Maria K. Serebryakova

Institute of Experimental Medicine (FSBSI "IEM") St. Petersburg Russia

A

Andrey S. Trulioff

Institute of Experimental Medicine (FSBSI "IEM") St. Petersburg Russia

I

Igor V. Kudryavtsev

Institute of Experimental Medicine (FSBSI "IEM") St. Petersburg Russia; Far Eastern Federal University (FEFU) Vladivostok Russia

N

Natalia Klebnikova

Occupational Pathology and Human Ecology (RIHOPHE) Research Institute of Hygiene St. Petersburg Russia

I

Irina Kruchinina

Institute of Silicate Chemistry Russian Academy of Sciences St. Petersburg Russia

P

Per E. Schwarze

Department of Air Pollution and Noise Norwegian Institute of Public Health Oslo Norway

M

Magne Refsnes

Department of Air Pollution and Noise Norwegian Institute of Public Health Oslo Norway

Cite This Article

Tonje Skuland, Tatiana Maslennikova, Marit Låg, et al. (2019). Synthetic hydrosilicate nanotubes induce low pro‐inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures. Basic & Clinical Pharmacology & Toxicology, 126(4), 374-388. https://doi.org/10.1111/bcpt.13341

Synthetic hydrosilicate nanotubes induce low pro‐inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures

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