Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas—Same Entity or First Cousins?

Sanda Alexandrescu; Andrey Korshunov; Siang Hui Lai; Salma Dabiri; Sushama Patil; Rong Li; Chie‐Schin Shih; Jose M. Bonnin; Jonathan A. Baker; Emma Du; David W. Scharnhorst; David Samuel; David W. Ellison; Arie Perry

doi:10.1111/bpa.12295

journal article Sep 22, 2015

Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas—Same Entity or First Cousins?

Sanda Alexandrescu Andrey Korshunov Siang Hui Lai Salma Dabiri Sushama Patil Rong Li

Chie‐Schin Shih Jose M. Bonnin Jonathan A. Baker Emma Du David W. Scharnhorst David Samuel David W. Ellison

Arie Perry

Brain Pathology Vol. 26 No. 2 pp. 215-223 · Wiley

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Abstract

AbstractEpithelioid glioblastoma (eGBM) and pleomorphic xanthoastrocytoma (PXA) with anaplastically transformed foci (ePXA) show overlapping features. Eleven eGBMs and 5 ePXAs were reviewed and studied immunohistochemically. Fluorescence in situ hybridization for EGFR amplification, PTEN deletion and ODZ3 deletion was also performed, with Ilumina 450 methylome analysis obtained in five cases. The average age for eGBM was 30.9 (range 2–79) years, including five pediatric cases and a M : F ratio of 4.5. The ePXA patients had a M : F ratio of 4 and averaged 21.2 (range 10–38) years in age, including two pediatric cases. Six eGBMs and two ePXAs recurred (median recurrence interval of 12 and 3.3 months, respectively). All tumors were composed of solid sheets of loosely cohesive, “melanoma‐like” cells with only limited infiltration. ePXAs showed lower grade foci with classic features of PXA. Both tumor types showed focal expression of epithelial and glial markers, retained INI1 and BRG1 expression, occasional CD34 positivity, and lack of mutant IDH1 (R132H) immunoreactivity. BRAF V600E mutation was present in four eGBMs and four ePXAs. ODZ3 deletion was detected in seven eGBMs and two ePXAs. EGFR amplification was absent. Methylome analysis showed that one ePXA and one eGBM clustered with PXAs, one eGBM clustered with low‐grade gliomas, and two eGBMs clustered with pediatric‐type glioblastomas. Common histologic, immunohistochemical, molecular and clinical features found in eGBM and ePXA suggest that they are closely related or the same entity. If the latter is true, the nomenclature and WHO grading remains to be resolved.

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References

27

[1]

10.3171/2013.3.jns121773

[2]

10.1111/nan.12093

[3]

10.1080/02688699908540631

[4]

10.1007/s11060-013-1176-5

[5]

10.1371/journal.pone.0017948

[6]

10.1007/bf00692844

[7]

10.1111/j.1750-3639.1993.tb00753.x

[8]

10.1097/pas.0b013e31827f9c5e

[9]

10.1097/pas.0b013e3181ce107b

[10]

10.1007/s00401-015-1405-4

[11]

10.1016/s0967-5868(03)00030-4

[12]

10.1200/jco.2013.51.1766

[13]

10.1210/jc.2012-1184

[14]

Louis DN (2007)

[15]

10.1016/j.jns.2006.11.008

[16]

10.1038/nature10910

[17]

10.1007/s10014-010-0010-4

[18]

10.1002/gcc.20485

[19]

10.1111/bpa.12114

[20]

10.1097/nen.0000000000000188

[21]

10.1186/1471-2407-14-258

[22]

10.1002/cncr.23899

[23]

10.1097/00000478-199110000-00002

[24]

10.1016/j.ccr.2012.08.024

[25]

10.1111/bpa.12173

[26]

10.1007/s10014-014-0192-2

[27]

Wyatt‐Ashmead J "Rhabdoid glioblastoma" Clin Neuropathol (2001)

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Details

Published: Sep 22, 2015
Vol/Issue: 26(2)
Pages: 215-223
License: View

Authors

S

Sanda Alexandrescu

Department of Pathology University of California San Francisco CA

A

Andrey Korshunov

Clinical Cooperation Unit Neuropathology German Cancer Research Center (DKFZ) Heidelberg Germany; Department of Neuropathology Heidelberg University Hospital Heidelberg Germany

S

Siang Hui Lai

Department of Pathology Singapore General Hospital Singapore

S

Salma Dabiri

Department of Pathology Good Samaritan Hospital San Jose CA

S

Sushama Patil

Department of Pathology Apollo Specialty Hospital Chennai India

R

Rong Li

Department of Pathology Children's Hospital of Alabama Birmingham AL

C

Chie‐Schin Shih

Department of Pediatrics Indiana University Indianapolis IN

J

Jose M. Bonnin

Department of Pathology Indiana University Indianapolis IN

J

Jonathan A. Baker

Department of Pathology Texas Health Presbyterian Hospital Dallas TX

E

Emma Du

Department of Pathology Scripps Clinic La Jolla CA

D

David W. Scharnhorst

Department of Pathology Children's Hospital Central California Madera CA

D

David Samuel

Department of Pediatric Oncology Children's Hospital Central California Madera CA

D

David W. Ellison

Department of Pathology St. Jude Children's Research Hospital Memphis TN

A

Arie Perry

Department of Pathology University of California San Francisco CA

Cite This Article

Sanda Alexandrescu, Andrey Korshunov, Siang Hui Lai, et al. (2015). Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas—Same Entity or First Cousins?. Brain Pathology, 26(2), 215-223. https://doi.org/10.1111/bpa.12295

Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas—Same Entity or First Cousins?

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