journal article Sep 04, 2009

Brain Extracellular Matrix in Neurodegeneration

Brain Pathology Vol. 19 No. 4 pp. 573-585 · Wiley
View at Publisher Save 10.1111/j.1750-3639.2008.00195.x
Abstract
AbstractThe role of extracellular matrix (ECM) in neurological development, function and degeneration has evolved from a simplistic physical adhesion to a system of intricate cellular signaling. While most cells require ECM adhesion to survive, it is now clear that differentiated function is intimately dependent upon cellular interaction with the ECM. Therefore, it is not surprising that the ECM is increasingly found to be involved in the enigmatic process of neurodegeneration. Descriptive studies of human neurodegenerative disorders and experimental studies of animal models of neurodegeneration have begun to define potential mechanisms of ECM disruption that can lead to synaptic and neuronal loss.
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Details
Published
Sep 04, 2009
Vol/Issue
19(4)
Pages
573-585
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Cite This Article
Dafna Bonneh‐Barkay, Clayton A. Wiley (2009). Brain Extracellular Matrix in Neurodegeneration. Brain Pathology, 19(4), 573-585. https://doi.org/10.1111/j.1750-3639.2008.00195.x