Pet ownership is associated with increased risk of non‐atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort

S. M. Collin; R. Granell; C. Westgarth; J. Murray; E. Paul; J. A. C. Sterne; A. John Henderson

doi:10.1111/cea.12380

journal article Dec 26, 2014

Pet ownership is associated with increased risk of non‐atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort

S. M. Collin R. Granell C. Westgarth J. Murray E. Paul J. A. C. Sterne A. John Henderson

Clinical & Experimental Allergy Vol. 45 No. 1 pp. 200-210 · Wiley

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Abstract

SummaryBackgroundStudies have shown an inverse association of pet ownership with allergy but inconclusive findings for asthma.ObjectiveTo investigate whether pet ownership during pregnancy and childhood was associated with asthma and atopy at the age of 7 in a UK population‐based birth cohort.MethodsData from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time points from pregnancy to the age of 7 with asthma, atopy (grass, house dust mite, and cat skin prick test) and atopic vs. non‐atopic asthma at the age of 7 using logistic regression models adjusted for child's sex, maternal history of asthma/atopy, maternal smoking during pregnancy, and family adversity.ResultsA total of 3768 children had complete data on pet ownership, asthma, and atopy. Compared with non‐ownership, continuous ownership of any pet (before and after the age of 3) was associated with 52% lower odds of atopic asthma [odds ratio (OR) 0.48, 95% CI 0.34–0.68]. Pet ownership tended to be associated with increased risk of non‐atopic asthma, particularly rabbits (OR 1.61, 1.04–2.51) and rodents (OR 1.86, 1.15–3.01), comparing continuous vs. non‐ownership. Pet ownership was consistently associated with lower odds of sensitization to grass, house dust mite, and cat allergens, but rodent ownership was associated with higher odds of sensitization to rodent allergen. Differential effects of pet ownership on atopic vs. non‐atopic asthma were evident for all pet types.Conclusions and Clinical RelevancePet ownership during pregnancy and childhood in this birth cohort was consistently associated with a reduced risk of aeroallergen sensitization and atopic asthma at the age of 7, but tended to be associated (particularly for rabbits and rodents) with an increased risk of non‐atopic asthma. The opposing effects on atopy vs. non‐atopic asthma might be considered by parents when they are deciding whether to acquire a pet.

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55

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References

Details

Published: Dec 26, 2014
Vol/Issue: 45(1)
Pages: 200-210
License: View

Authors

S

S. M. Collin

School of Social & Community Medicine University of Bristol Bristol UK

R

R. Granell

School of Social & Community Medicine University of Bristol Bristol UK

C

C. Westgarth

Institute of Infection and Global Health University of Liverpool Liverpool UK

J

J. Murray

School of Veterinary Science University of Bristol Bristol UK

E

E. Paul

School of Veterinary Science University of Bristol Bristol UK

J

J. A. C. Sterne

School of Social & Community Medicine University of Bristol Bristol UK

A

A. John Henderson

School of Social & Community Medicine University of Bristol Bristol UK

Funding

National Institutes of Health Award: 4R03HD70663-2

Cite This Article

S. M. Collin, R. Granell, C. Westgarth, et al. (2014). Pet ownership is associated with increased risk of non‐atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort. Clinical & Experimental Allergy, 45(1), 200-210. https://doi.org/10.1111/cea.12380

Pet ownership is associated with increased risk of non‐atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort

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