Stem cell therapy: a promising biological strategy for tendon–bone healing after anterior cruciate ligament reconstruction

Zi‐Chen Hao; Shan‐Zheng Wang; Xue‐Jun Zhang; Jun Lu

doi:10.1111/cpr.12242

journal article Mar 01, 2016

Stem cell therapy: a promising biological strategy for tendon–bone healing after anterior cruciate ligament reconstruction

Zi‐Chen Hao Shan‐Zheng Wang Xue‐Jun Zhang Jun Lu

Cell Proliferation Vol. 49 No. 2 pp. 154-162 · Wiley

View at Publisher Save 10.1111/cpr.12242

Abstract

AbstractTendon–bone healing after anterior cruciate ligament (ACL) reconstruction is a complex process, impacting significantly on patients' prognosis. Natural tendon–bone healing usually results in fibrous scar tissue, which is of inferior quality compared to native attachment. In addition, the early formed fibrous attachment after surgery is often not reliable to support functional rehabilitation, which may lead to graft failure or unsatisfied function of the knee joint. Thus, strategies to promote tendon–bone healing are crucial for prompt and satisfactory functional recovery. Recently, a variety of biological approaches, including active substances, gene transfer, tissue engineering and stem cells, have been proposed and applied to enhance tendon–bone healing. Among these, stem cell therapy has been shown to have promising prospects and draws increasing attention. From commonly investigated bone marrow‐derived mesenchymal stem cells (bMSCs) to emerging ACL‐derived CD34+ stem cells, multiple stem cell types have been proven to be effective in accelerating tendon–bone healing. This review describes the current understanding of tendon–bone healing and summarizes the current status of related stem cell therapy. Future limitations and perspectives are also discussed.

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Details

Published: Mar 01, 2016
Vol/Issue: 49(2)
Pages: 154-162
License: View

Authors

Z

Zi‐Chen Hao

Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China

S

Shan‐Zheng Wang

Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China

X

Xue‐Jun Zhang

Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China

J

Jun Lu

Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China; Surgical Research Center Medical School of Southeast University Nanjing 210009 China

Funding

Department of Orthopaedics, Zhongda Hospital, Medical School of Southeast University, China

Cite This Article

Zi‐Chen Hao, Shan‐Zheng Wang, Xue‐Jun Zhang, et al. (2016). Stem cell therapy: a promising biological strategy for tendon–bone healing after anterior cruciate ligament reconstruction. Cell Proliferation, 49(2), 154-162. https://doi.org/10.1111/cpr.12242

Stem cell therapy: a promising biological strategy for tendon–bone healing after anterior cruciate ligament reconstruction

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