Emerging roles of circular RNAs in neuropathic pain

Derong Xu; Xuexiao Ma; Chong Sun; Jialuo Han; Chuanli Zhou; Matthew T. V. Chan; William K. K. Wu

doi:10.1111/cpr.13139

journal article Open Access Oct 08, 2021

Emerging roles of circular RNAs in neuropathic pain

Derong Xu

Xuexiao Ma

Chong Sun

Jialuo Han Chuanli Zhou

Matthew T. V. Chan William K. K. Wu

Cell Proliferation Vol. 54 No. 12 · Wiley

View at Publisher Save 10.1111/cpr.13139

Abstract

AbstractNeuropathic pain is a major type of chronic pain caused by the disease or injury of the somatosensory nervous system. It afflicts about 10% of the general population with a significant proportion of patients’ refractory to conventional medical treatment. This highlights the importance of a better understanding of the molecular pathogenesis of neuropathic pain so as to drive the development of novel mechanism‐driven therapy. Circular RNAs (circRNAs) are a type of non‐coding, regulatory RNAs that exhibit tissue‐ and disease‐specific expression. An increasing number of studies reported that circRNAs may play pivotal roles in the development of neuropathic pain. In this review, we first summarize circRNA expression profiling studies on neuropathic pain. We also highlight the molecular mechanisms of specific circRNAs (circHIPK3, circAnks1a, ciRS‐7, cZRANB1, circZNF609 and circ_0005075) that play key functional roles in the pathogenesis of neuropathic pain and discuss their potential diagnostic, prognostic, and therapeutic utilization in the clinical management of neuropathic pain.

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References

70

[1]

10.2147/jpr.s285870

[2]

10.1007/s12264-020-00621-4

[3]

10.1016/j.bja.2020.10.032

[4]

Zhang JY "LncRNA SNHG1 attenuates neuropathic pain following spinal cord injury by regulating CDK4 level" Eur Rev Med Pharmacol Sci (2020)

[5]

10.3389/fphar.2020.602417

[6]

10.1016/j.neuroscience.2020.12.021

[7]

Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons

Ti-Yen Yeh, I-Wei Luo, Yu-Lin Hsieh et al.

Cells 10.3390/cells9122725

[8]

10.1016/j.jneuroim.2020.577458

[9]

LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression

Shuyue Xian, Ruiwen Ding, Mengyun Li et al.

Journal of Neuroimmunology 10.1016/j.jneuroim.2020.577457

[10]

Wu Y "miR‐590‐3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells" Acta Biochim Pol (2020)

[11]

10.1155/2020/6661642

[12]

10.1186/s13578-020-00501-4

[13]

10.1155/2020/8309745

[14]

10.3389/fnins.2020.570831

[15]

10.1139/cjpp-2020-0036

[16]

10.3892/mmr.2020.11742

[17]

10.1590/0004-282x20200166

[18]

10.3892/etm.2020.9567

[19]

Naccache DD "Cannabis alleviates neuropathic pain and reverses weight loss in diabetic neuropathic cachexia in a previous heroin abuser" Endocrinol Diabetes Metabol Case Rep (2020)

[20]

10.1097/md.0000000000023725

[21]

10.3389/fneur.2020.564643

[22]

Liu M "Stem cells in the treatment of neuropathic pain: research progress of mechanism" Stem Cells Int (2020) 10.1155/2020/8861251

[23]

10.18632/aging.202144

[24]

10.1590/0001-3765202020191155

[25]

10.1002/edm2.209

[26]

10.1016/j.jbspin.2021.105222

[27]

Protective role of natural killer cells in neuropathic pain conditions

Josephine Lassen, Klarissa Hanja Stürner, Janne Gierthmühlen et al.

Pain 10.1097/j.pain.0000000000002274

[28]

10.1093/pm/pnab060

[29]

10.2147/jpr.s285609

[30]

10.1111/cpr.12548

[31]

10.1007/s11011-021-00775-8

[32]

10.1111/cpr.12704

[33]

10.1111/cpr.12661

[34]

10.1111/cpr.12720

[35]

10.1080/13880209.2021.1893347

[36]

10.1002/brb3.2048

[37]

10.1111/cpr.12936

[38]

10.1111/cpr.12815

[39]

10.1111/cpr.12736

[40]

10.1007/s11356-019-06489-w

[41]

10.1111/cpr.12648

[42]

10.1111/cpr.12981

[43]

10.1111/cpr.12521

[44]

Li X "A novel identified circ‐ANKHD1 targets the miR‐27a‐3p/SFRP1 signaling pathway and modulates the apoptosis of granulosa cells" Environ Sci Pollut Res Int (2021)

[45]

10.1111/cpr.12614

[46]

10.1111/cpr.13047

[47]

10.1016/j.gene.2020.145079

[48]

10.3389/fnmol.2017.00091

[49]

10.2147/jpr.s139592

[50]

10.2147/jpr.s221615

Showing 50 of 70 references

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Details

Published: Oct 08, 2021
Vol/Issue: 54(12)
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Authors

D

Derong Xu