Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets

Zhijing Wu; Ruixin Zhou; Baizao Li; Mingyu Cao; Wenlong Wang; Xinying Li

doi:10.1111/cpr.13692

journal article Open Access Jun 28, 2024

Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets

Zhijing Wu

Ruixin Zhou Baizao Li Mingyu Cao Wenlong Wang

Xinying Li

Cell Proliferation Vol. 57 No. 9 · Wiley

View at Publisher Save 10.1111/cpr.13692

Abstract

AbstractHigh‐throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning the development of these diseases remain largely elusive. This review sheds light on the roles of several tRNA methylations (m1A, m3C, m5C, m1G, m2G, m7G, m5U, and Nm) in diverse biological functions, including metabolic processing, stability, protein interactions, and mitochondrial activities. It further outlines diseases linked to aberrant tRNA modifications, related enzymes, and potential underlying mechanisms. Moreover, disruptions in tRNA regulation and abnormalities in tRNA‐derived small RNAs (tsRNAs) contribute to disease pathogenesis, highlighting their potential as biomarkers for disease diagnosis. The review also delves into the exploration of drugs development targeting tRNA methylation enzymes, emphasizing the therapeutic prospects of modulating these processes. Continued research is imperative for a comprehensive comprehension and integration of these molecular mechanisms in disease diagnosis and treatment.

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References

224

[1]

Role of RNA modifications in cancer

Isaia Barbieri, Tony Kouzarides

Nature Reviews Cancer 10.1038/s41568-020-0253-2

[2]

10.1038/25779

[3]

10.1016/j.cell.2023.05.028

[4]

10.1016/j.csbj.2022.12.020

[5]

10.1038/s41419-020-03314-y

[6]

10.3390/biom7020035

[7]

tRNA modifications: insights into their role in human cancers

Ye Wang, En-Wei Tao, Juan Tan et al.

Trends in Cell Biology 10.1016/j.tcb.2023.04.002

[8]

10.1093/nar/gkab1083

[9]

10.1016/s0300-9084(76)80387-2

[10]

10.1038/s41580-021-00342-0

[11]

tRNA dysregulation and disease

Esteban A. Orellana, Elisabeth Siegal, Richard I. Gregory

Nature Reviews Genetics 10.1038/s41576-022-00501-9

[12]

10.1016/j.abb.2021.109083

[13]

10.3389/fmolb.2021.659388

[14]

10.4155/fmc-2018-0404

[15]

10.1016/j.csbj.2022.11.045

[16]

10.1261/rna.035600.112

[17]

10.3390/genes10020100

[18]

10.1261/rna.072090.119

[19]

10.1016/j.molcel.2018.08.011

[20]

10.1080/15476286.2020.1779492

[21]

10.1242/jcs.223891

[22]

10.1038/s41556-021-00709-7

[23]

10.1093/jmcb/mjv029

[24]

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia, Ye Fu, Xu Zhao et al.

Nature Methods 10.1038/nchembio.687

[25]

10.1021/acs.analchem.8b01703

[26]

10.1038/s41589-022-00976-x

[27]

10.1038/s41467-022-29790-8

[28]

10.1038/s41467-021-26718-6

[29]

10.1038/onc.2015.244

[30]

10.1093/nar/gky1250

[31]

10.1038/s41598-023-39935-4

[32]

10.1038/s41590-022-01302-2

[33]

10.1038/s41590-022-01301-3

[34]

10.1021/acscentsci.1c00351

[35]

10.1038/s41467-018-06471-z

[36]

10.1093/hmg/ddab357

[37]

10.1093/nar/gkab879

[38]

10.1038/s41598-019-45079-1

[39]

10.1016/j.envint.2023.108038

[40]

10.1038/s41598-022-05648-3

[41]

10.3390/genes13030421

[42]

10.3390/ijms232213851

[43]

10.1016/j.tibs.2022.03.004

[44]

10.1074/jbc.m117.798298

[45]

10.1093/nar/gkab603

[46]

10.1038/s41467-020-16321-6

[47]

10.1016/j.bbrc.2021.12.013

[48]

10.1016/j.molcel.2021.10.018

[49]

10.1038/s41467-021-27905-1

[50]

10.1038/s42003-021-02890-9

Showing 50 of 224 references

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Details

Published: Jun 28, 2024
Vol/Issue: 57(9)
License: View

Authors

Z

Zhijing Wu

Department of General Surgery, Xiangya Hospital Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan China

R

Ruixin Zhou

Department of General Surgery, Xiangya Hospital Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan China

B

Baizao Li

Department of General Surgery, Xiangya Hospital Central South University Changsha Hunan China

M

Mingyu Cao

Department of General Surgery, Xiangya Hospital Central South University Changsha Hunan China

W

Wenlong Wang

Department of Breast Surgery, Xiangya Hospital Central South University Changsha Hunan China; Clinical Research Center for Breast Cancer in Hunan Province Changsha Hunan China

X

Xinying Li

Department of General Surgery, Xiangya Hospital Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan China

Funding

National Natural Science Foundation of China Award: 82270835

China Postdoctoral Science Foundation Award: GZC20233156

Cite This Article

Zhijing Wu, Ruixin Zhou, Baizao Li, et al. (2024). Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets. Cell Proliferation, 57(9). https://doi.org/10.1111/cpr.13692

Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets

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