Advances in gut–brain organ chips

Yu Zhang; Si‐Ming Lu; Jian‐Jian Zhuang; Li‐Guo Liang

doi:10.1111/cpr.13724

journal article Open Access Jul 31, 2024

Advances in gut–brain organ chips

Yu Zhang

Si‐Ming Lu

Jian‐Jian Zhuang Li‐Guo Liang

Cell Proliferation Vol. 57 No. 9 · Wiley

View at Publisher Save 10.1111/cpr.13724

Abstract

AbstractThe brain and gut are sensory organs responsible for sensing, transmitting, integrating, and responding to signals from the internal and external environment. In‐depth analysis of brain–gut axis interactions is important for human health and disease prevention. Current research on the brain–gut axis primarily relies on animal models. However, animal models make it difficult to study disease mechanisms due to inherent species differences, and the reproducibility of experiments is poor because of individual animal variations, which leads to a significant limitation of real‐time sensory responses. Organ‐on‐a‐chip platforms provide an innovative approach for disease treatment and personalized research by replicating brain and gut ecosystems in vitro. This enables a precise understanding of their biological functions and physiological responses. In this article, we examine the history and most current developments in brain, gut, and gut–brain chips. The importance of these systems for understanding pathophysiology and developing new drugs is emphasized throughout the review. This article also addresses future directions and present issues with the advancement and application of gut–brain‐on‐a‐chip technologies.

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Published: Jul 31, 2024
Vol/Issue: 57(9)
License: View

Authors

Y

Yu Zhang

Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University Hangzhou China; Department of Pharmacy, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University Hangzhou China

S

Si‐Ming Lu

Department of Laboratory Medicine, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China; Zhejiang Key Laboratory of Clinical In Vitro Diagnostic Techniques Hangzhou China; Institute of Laboratory Medicine Zhejiang University Hangzhou China

J

Jian‐Jian Zhuang

Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University Hangzhou China; Department of Pharmacy, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University Hangzhou China

L

Li‐Guo Liang

Centre for Clinical Laboratory The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China; National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

Cite This Article

Yu Zhang, Si‐Ming Lu, Jian‐Jian Zhuang, et al. (2024). Advances in gut–brain organ chips. Cell Proliferation, 57(9). https://doi.org/10.1111/cpr.13724

Advances in gut–brain organ chips

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