Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Xuemei Long; Dan Tan; Qianke Tao; Qiaonan Ye; Luwen Ye; Qing Li; Jingang Xiao

doi:10.1111/cpr.70178

journal article Open Access Feb 03, 2026

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Xuemei Long

Dan Tan

Qianke Tao Qiaonan Ye

Luwen Ye Qing Li

Jingang Xiao

Cell Proliferation Vol. 59 No. 4 · Wiley

View at Publisher Save 10.1111/cpr.70178

Abstract

ABSTRACT
Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems. Conventional therapeutic approaches, including anti‐resorptive drugs and surgical interventions, face limitations such as long‐term medication requirements, adverse effects (e.g., bisphosphonate‐related osteonecrosis of the jaw) and suboptimal efficacy. Bone marrow mesenchymal stromal cells (BMSCs) have emerged as a promising therapeutic alternative due to their accessibility, multi‐lineage differentiation potential, immunomodulatory properties and homing capacity. However, challenges such as disease complexity, mechanistic heterogeneity and therapeutic inconsistency hinder their clinical translation. Recent advances in genetic engineering, preconditioning strategies, bone tissue engineering (e.g., three‐dimensional [3D] scaffolding), extracellular vesicle‐based therapies and epigenetic regulation (e.g., histone modification) have significantly enhanced the therapeutic effects of BMSCs. Furthermore, cutting‐edge technologies like organoids and 3D bioprinting, which stem from advances in tissue engineering, offer novel avenues for clinical applications. Given these rapid developments, this review systematically summarises BMSC‐based treatment strategies for bone‐related diseases, discusses current challenges and outlines future directions to advance translational research.

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Details

Published: Feb 03, 2026
Vol/Issue: 59(4)
License: View

Authors

X

Xuemei Long

Department of Oral Implantology, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China

D

Dan Tan

Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China; Department of Periodontal and Mucosal Diseases, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China

Q

Qianke Tao

Department of Plastic and Burn Surgery, The Affiliated Hospital Southwest Medical University Luzhou China

Q

Qiaonan Ye

Department of Plastic and Burn Surgery, The Affiliated Hospital Southwest Medical University Luzhou China

L

Luwen Ye

Department of Oral Implantology, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China

Q

Qing Li

Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China

J

Jingang Xiao

Department of Oral Implantology, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China; Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital Southwest Medical University Luzhou China

Funding

National Natural Science Foundation of China Award: 82370938

Science and Technology Department of Sichuan Province Award: 2024NSFSC2087

Cite This Article

Xuemei Long, Dan Tan, Qianke Tao, et al. (2026). Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases. Cell Proliferation, 59(4). https://doi.org/10.1111/cpr.70178

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

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