Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation

Di Ye; Timothy J. Fairchild; Lechi Vo; Peter D. Drummond

doi:10.1111/dme.14729

journal article Oct 28, 2021

Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation

Di Ye

Timothy J. Fairchild

Lechi Vo

Peter D. Drummond

Diabetic Medicine Vol. 39 No. 1 · Wiley

View at Publisher Save 10.1111/dme.14729

Abstract

AbstractAimsDiabetic peripheral neuropathy (DPN) occurs in about half of people with diabetes, of whom a quarter may develop chronic pain. Pain may remain for years yet be difficult to treat because the underlying mechanisms remain unclear. There is consensus that processing excessive glucose leads to oxidative stress, interfering with normal metabolism. In this narrative review, we argue that oxidative stress may also contribute to pain.MethodsWe reviewed literature in PubMed published between January 2005 and August 2021.Results and conclusionsIn diabetes, hyperglycaemia and associated production of reactive species can directly increase pain signalling and activate sensory neurons; or the effects can be indirect, mediated by mitochondrial damage and enhanced inflammation. Furthermore, pain processing in the central nervous system is compromised in painful DPN. This is implicated in central sensitisation and dysfunctional pain modulation. However, central pain modulatory function is understudied in diabetes. Future research is required to clarify whether central sensitisation and/or disturbances in central pain modulation contribute to painful DPN. Positive results would facilitate early detection and future treatment.

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Cited By

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High Blood Glucose and Excess Body fat Enhance Pain Sensitivity and Weaken Pain Inhibition in Healthy Adults: A Single-blind Cross-over Randomized Controlled Trial

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Metrics

43

Citations

57

References

Details

Published: Oct 28, 2021
Vol/Issue: 39(1)
License: View

Authors

D

Di Ye

Discipline of Psychology and Healthy Ageing Research Centre College of Science, Health, Engineering and Education Murdoch University Murdoch Western Australia Australia

T

Timothy J. Fairchild

Discipline of Exercise Science and Healthy Ageing Research Centre College of Science, Health, Engineering and Education Murdoch University Murdoch Western Australia Australia

L

Lechi Vo

Discipline of Psychology and Healthy Ageing Research Centre College of Science, Health, Engineering and Education Murdoch University Murdoch Western Australia Australia

P

Peter D. Drummond

Discipline of Psychology and Healthy Ageing Research Centre College of Science, Health, Engineering and Education Murdoch University Murdoch Western Australia Australia

Funding

Murdoch University

Cite This Article

Di Ye, Timothy J. Fairchild, Lechi Vo, et al. (2021). Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation. Diabetic Medicine, 39(1). https://doi.org/10.1111/dme.14729

Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation

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