The fitness costs of antibiotic resistance mutations

Anita H. Melnyk; Alex Wong; Rees Kassen

doi:10.1111/eva.12196

journal article Open Access Aug 27, 2014

The fitness costs of antibiotic resistance mutations

Anita H. Melnyk Alex Wong

Rees Kassen

Evolutionary Applications Vol. 8 No. 3 pp. 273-283 · Wiley

View at Publisher Save 10.1111/eva.12196

Abstract

AbstractAntibiotic resistance is increasing in pathogenic microbial populations and is thus a major threat to public health. The fate of a resistance mutation in pathogen populations is determined in part by its fitness. Mutations that suffer little or no fitness cost are more likely to persist in the absence of antibiotic treatment. In this review, we performed a meta‐analysis to investigate the fitness costs associated with single mutational events that confer resistance. Generally, these mutations were costly, although several drug classes and species of bacteria on average did not show a cost. Further investigations into the rate and fitness values of compensatory mutations that alleviate the costs of resistance will help us to better understand both the emergence and management of antibiotic resistance in clinical settings.

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627

Citations

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References

Details

Published: Aug 27, 2014
Vol/Issue: 8(3)
Pages: 273-283
License: View

Authors

A

Anita H. Melnyk

Centre for Advanced Research in Environmental Genomics Department of Biology University of Ottawa Ottawa ON Canada

A

Alex Wong

Department of Biology Carleton University Ottawa ON Canada

R

Rees Kassen

Centre for Advanced Research in Environmental Genomics Department of Biology University of Ottawa Ottawa ON Canada

Funding

Natural Sciences and Engineering Research Council of Canada Award: RGPIN-298357-2009

Cite This Article

Anita H. Melnyk, Alex Wong, Rees Kassen (2014). The fitness costs of antibiotic resistance mutations. Evolutionary Applications, 8(3), 273-283. https://doi.org/10.1111/eva.12196

The fitness costs of antibiotic resistance mutations

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