Salivary hypofunction: An update on therapeutic strategies

Fernanda G. Salum; Francisco de Assis Carvalho Medella‐Junior; Maria A. Zancanaro Figueiredo; Karen Cherubini

doi:10.1111/ger.12353

journal article Jun 29, 2018

Salivary hypofunction: An update on therapeutic strategies

Fernanda G. Salum Francisco de Assis Carvalho Medella‐Junior

Maria A. Zancanaro Figueiredo Karen Cherubini

Gerodontology Vol. 35 No. 4 pp. 305-316 · Wiley

View at Publisher Save 10.1111/ger.12353

Abstract

ObjectiveTo perform a literature review addressing the therapeutic strategies for salivary hypofunction.BackgroundQualitative and quantitative salivary dysfunctions predispose to changes in the oral mucosa and teeth, cause impairment to oral functions and negative impact on quality of life.Materials and methodsA MEDLINE/PubMed search was conducted using the terms “Xerostomia” AND, “Saliva Artificial” OR, “Citric Acid,” “Malic Acid,” “Chewing Gum,” “Acupuncture” OR, “Pilocarpine” OR, “Bethanechol” OR, “Cevimeline” OR, “Hyperbaric Oxygen Therapy” OR, “Stem Cell Therapy” OR “Genetic Therapy” and their Mesh Terms.ResultsWe selected 25 clinical trials investigating the effects of salivary substitutes, chewing gum, malic and citric acids, pilocarpine, cevimeline, bethanechol, acupuncture, hyperbaric oxygen therapy and regenerative therapies on salivary hypofunction. In most studies, the number of participants was low and the follow‐up times short. The therapeutic modalities were classified according to the level of evidence on salivary dysfunction.ConclusionsPilocarpine and cevimeline had the strongest evidence of beneficial effect on salivary hypofunction. Citric and malic acids increase salivary flow but also increase the risk of erosion and dental caries. There are no controlled clinical trials supporting the efficacy of acupuncture, stem cell therapy and gene therapy on salivary dysfunction, although clinical observations suggest a promising effect. There is no evidence supporting salivary substitutes, chewing gum, bethanechol or hyperbaric oxygen on the treatment of salivary hypofunction.

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Details

Published: Jun 29, 2018
Vol/Issue: 35(4)
Pages: 305-316
License: View

Authors

F

Fernanda G. Salum

Oral Medicine Division Pontifical Catholic University of Rio Grande do Sul‐PUCRS Rio Grande do Sul Brazil

F

Francisco de Assis Carvalho Medella‐Junior

Oral Medicine Division Pontifical Catholic University of Rio Grande do Sul‐PUCRS Rio Grande do Sul Brazil

M

Maria A. Zancanaro Figueiredo

Oral Medicine Division Pontifical Catholic University of Rio Grande do Sul‐PUCRS Rio Grande do Sul Brazil

K

Karen Cherubini

Oral Medicine Division Pontifical Catholic University of Rio Grande do Sul‐PUCRS Rio Grande do Sul Brazil

Cite This Article

Fernanda G. Salum, Francisco de Assis Carvalho Medella‐Junior, Maria A. Zancanaro Figueiredo, et al. (2018). Salivary hypofunction: An update on therapeutic strategies. Gerodontology, 35(4), 305-316. https://doi.org/10.1111/ger.12353

Salivary hypofunction: An update on therapeutic strategies

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