Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning

Henry H. Yin; Barbara J. Knowlton; Bernard W. Balleine

doi:10.1111/j.1460-9568.2004.03095.x

journal article Jan 01, 2004

Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning

Henry H. Yin Barbara J. Knowlton Bernard W. Balleine

European Journal of Neuroscience Vol. 19 No. 1 pp. 181-189 · Wiley

View at Publisher Save 10.1111/j.1460-9568.2004.03095.x

Abstract

AbstractHabits are controlled by antecedent stimuli rather than by goal expectancy. Interval schedules of feedback have been shown to generate habits, as revealed by the insensitivity of behaviour acquired under this schedule to outcome devaluation treatments. Two experiments were conducted to assess the role of the dorsolateral striatum in habit learning. In Experiment 1, sham operated controls and rats with dorsolateral striatum lesions were trained to press a lever for sucrose under interval schedules. After training, the sucrose was devalued by inducing taste aversion to it using lithium chloride, whereas saline injections were given to the controls. Only rats given the devaluation treatment reduced their consumption of sucrose and this reduction was similar in both the sham and the lesioned groups. All rats were then returned to the instrumental chamber for an extinction test, in which the lever was extended but no sucrose was delivered. In contrast to sham operated controls, rats with dorsolateral striatum lesions refrained from pressing the lever if the outcome was devalued. To assess the specificity of the role of dorsolateral striatum in this effect a second experiment was conducted in which a group with lesions of dorsomedial striatum was added. In relation now to both the sham and the dorsomedial lesioned groups, only rats with lesions of dorsolateral striatum significantly reduced responding after outcome devaluation. In conclusion, this study provides direct evidence that the dorsolateral striatum is necessary for habit formation. Furthermore, it suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal‐directed instrumental actions.

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References

Details

Published: Jan 01, 2004
Vol/Issue: 19(1)
Pages: 181-189
License: View

Authors

H

Henry H. Yin

Department of Psychology and Neuroscience, Duke University, Durham, NC 3; Duke Institute for Brain Sciences, Durham, NC 7; Department of Neurobiology, Duke University Medical Center, Durham, NC 8

Cite This Article

Henry H. Yin, Barbara J. Knowlton, Bernard W. Balleine (2004). Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. European Journal of Neuroscience, 19(1), 181-189. https://doi.org/10.1111/j.1460-9568.2004.03095.x

Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning

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