Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Yeonggwon Jo; Seung Hyeon Hwang; Jinah Jang

doi:10.3390/ijms22179367

journal article Open Access Aug 29, 2021

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Yeonggwon Jo

Seung Hyeon Hwang

Jinah Jang

International Journal of Molecular Sciences Vol. 22 No. 17 pp. 9367 · MDPI AG

View at Publisher Save 10.3390/ijms22179367

Abstract

Tissues and organs are not composed of solely cellular components; instead, they converge with an extracellular matrix (ECM). The composition and function of the ECM differ depending on tissue types. The ECM provides a microenvironment that is essential for cellular functionality and regulation. However, during aging, the ECM undergoes significant changes along with the cellular components. The ECM constituents are over- or down-expressed, degraded, and deformed in senescence cells. ECM aging contributes to tissue dysfunction and failure of stem cell maintenance. Aging is the primary risk factor for prevalent diseases, and ECM aging is directly or indirectly correlated to it. Hence, rejuvenation strategies are necessitated to treat various age-associated symptoms. Recent rejuvenation strategies focus on the ECM as the basic biomaterial for regenerative therapies, such as tissue engineering. Modified and decellularized ECMs can be used to substitute aged ECMs and cell niches for culturing engineered tissues. Various tissue engineering approaches, including three-dimensional bioprinting, enable cell delivery and the fabrication of transplantable engineered tissues by employing ECM-based biomaterials.

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Details

Published: Aug 29, 2021
Vol/Issue: 22(17)
Pages: 9367
License: View

Authors

Y

Yeonggwon Jo

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea

S

Seung Hyeon Hwang

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea

J

Jinah Jang

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea; Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea; Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul 03722, Korea

Funding

National Research Foundation of South Korea (NRF) grant funded by the Ministry of Science and ICT Award: No. 2021R1A2C2004981

Research Leader Program of the National Research Foundation of Korea (NRF) funded by the Korea government (MSIT) Award: 2020R1A3B2079741

Cite This Article

Yeonggwon Jo, Seung Hyeon Hwang, Jinah Jang (2021). Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations. International Journal of Molecular Sciences, 22(17), 9367. https://doi.org/10.3390/ijms22179367

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

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