Intracortical remodelling increases in highly loaded bone after exercise cessation

Raniere Gaia Costa da Silva; Tsim Christopher Sun; Ambika Prasad Mishra; Alan Boyde; Michael Doube; Christopher Michael Riggs

doi:10.1111/joa.13969

journal article Open Access Nov 12, 2023

Intracortical remodelling increases in highly loaded bone after exercise cessation

Raniere Gaia Costa da Silva

Christopher Michael Riggs

Journal of Anatomy Vol. 244 No. 3 pp. 424-437 · Wiley

View at Publisher Save 10.1111/joa.13969

Abstract

AbstractResorption within cortices of long bones removes excess mass and damaged tissue and increases during periods of reduced mechanical loading. Returning to high‐intensity exercise may place bones at risk of failure due to increased porosity caused by bone resorption. We used point‐projection X‐ray microscopy images of bone slices from highly loaded (metacarpal, tibia) and minimally loaded (rib) bones from 12 racehorses, 6 that died during a period of high‐intensity exercise and 6 that had a period of intense exercise followed by at least 35 days of rest prior to death, and measured intracortical canal cross‐sectional area (Ca.Ar) and number (N.Ca) to infer remodelling activity across sites and exercise groups. Large canals that are the consequence of bone resorption (Ca.Ar >0.04 mm2) were 1.4× to 18.7× greater in number and area in the third metacarpal bone from rested than exercised animals (p = 0.005–0.008), but were similar in number and area in ribs from rested and exercised animals (p = 0.575–0.688). An intermediate relationship was present in the tibia, and when large canals and smaller canals that result from partial bony infilling (Ca.Ar >0.002 mm2) were considered together. The mechanostat may override targeted remodelling during periods of high mechanical load by enhancing bone formation, reducing resorption and suppressing turnover. Both systems may work synergistically in rest periods to remove excess and damaged tissue.

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Details

Published: Nov 12, 2023
Vol/Issue: 244(3)
Pages: 424-437
License: View

Authors

R

Raniere Gaia Costa da Silva

Department of Infectious Diseases and Public Health City University of Hong Kong Kowloon Hong Kong

T

Tsim Christopher Sun

Sydney School of Veterinary Science University of Sydney Camperdown New South Wales Australia

A

Ambika Prasad Mishra

Department of Infectious Diseases and Public Health City University of Hong Kong Kowloon Hong Kong

A

Alan Boyde

Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

M

Michael Doube

Department of Infectious Diseases and Public Health City University of Hong Kong Kowloon Hong Kong

C

Christopher Michael Riggs

Equine Welfare Research Foundation The Hong Kong Jockey Club Sha Tin Hong Kong

Funding

Arthritis Research UK

Cite This Article

Raniere Gaia Costa da Silva, Tsim Christopher Sun, Ambika Prasad Mishra, et al. (2023). Intracortical remodelling increases in highly loaded bone after exercise cessation. Journal of Anatomy, 244(3), 424-437. https://doi.org/10.1111/joa.13969

Intracortical remodelling increases in highly loaded bone after exercise cessation

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