Microbiome in health and disease

Edward M Giles; Jenny Couper

doi:10.1111/jpc.14939

journal article Jun 05, 2020

Microbiome in health and disease

Edward M Giles

Jenny Couper

Journal of Paediatrics and Child Health Vol. 56 No. 11 pp. 1735-1738 · Wiley

View at Publisher Save 10.1111/jpc.14939

Abstract

There has been an exponential rise in research into the microbiota of the human gastrointestinal tract, particularly of the genomic content (the microbiome). The vast number of micro‐organisms residing in our gut has an integral role in essential processes, including growth and development. Probiotics, live micro‐organisms with putative benefits on health have become ubiquitous as treatments for many conditions, despite often limited robust clinical trial data. However, the resurgence of faecal microbial transplantation as an effective treatment modality provides further promise that manipulation of our microbiome can have clinical benefits. This review will present the recent evidence for the role of the microbiome in development and growth, and focus on the evidence for its manipulation in paediatric diseases. We will show that while there is promising data in specific diseases, there remain many unanswered questions. Only through a deeper understanding of our complex internal ecosystem will we be able to move to the next stage of targeted microbial therapy.

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References

35

[1]

Role of the microbiome in human development

Maria Gloria Dominguez-Bello, Filipa Godoy-Vitorino, Rob Knight et al.

Gut 10.1136/gutjnl-2018-317503

[2]

10.1038/s41586-018-0620-2

[3]

Temporal development of the gut microbiome in early childhood from the TEDDY study

Christopher J. Stewart, Nadim J. Ajami, Jacqueline L. O’Brien et al.

Nature 10.1038/s41586-018-0617-x

[4]

Time to consider the risks of caesarean delivery for long term child health

J. Blustein, J. Liu

BMJ 10.1136/bmj.h2410

[5]

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

Omry Koren, Julia K. Goodrich, Tyler C. Cullender et al.

Cell 10.1016/j.cell.2012.07.008

[6]

10.1126/scitranslmed.3008599

[7]

10.1016/j.jaci.2016.08.031

[8]

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

Shelly A. Buffington, Gonzalo Viana Di Prisco, Thomas A. Auchtung et al.

Cell 10.1016/j.cell.2016.06.001

[9]

10.1136/gutjnl-2018-317235

[10]

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

Els van Nood, Anne Vrieze, Max Nieuwdorp et al.

New England Journal of Medicine 10.1056/nejmoa1205037

[11]

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

Sudarshan Paramsothy, Michael A Kamm, Nadeem O Kaakoush et al.

The Lancet 10.1016/s0140-6736(17)30182-4

[12]

10.1001/jama.2018.20046

[13]

10.1542/peds.2017-1811

[14]

Guo Q "Probiotics for the prevention of pediatric antibiotic‐associated diarrhea" Cochrane Database Syst. Rev. (2019)

[15]

10.1542/peds.2013-3950

[16]

10.1111/pai.12982

[17]

10.1111/cea.12924

[18]

10.1002/ebch.1976

[19]

10.1542/peds.2010-0433

[20]

10.1001/jamapediatrics.2013.4367

[21]

10.1136/bmj.g2107

[22]

Alfaleh K "Probiotics for prevention of necrotizing enterocolitis in preterm infants" Cochrane Database Syst. Rev. (2014)

[23]

10.1542/peds.2013-1339

[24]

10.1016/s0140-6736(15)01027-2

[25]

10.1016/j.jpeds.2017.03.047

[26]

10.1111/apt.13590

[27]

10.1111/pai.12874

[28]

10.1016/s0140-6736(00)04259-8

[29]

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia, Clarissa Campbell, Xiying Fan et al.

Nature 10.1038/nature12726

[30]

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life

Tommi Vatanen, Damian R. Plichta, Juhi Somani et al.

Nature Microbiology 10.1038/s41564-018-0321-5

[31]

10.1111/pedi.12756

[32]

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Jotham Suez, Niv Zmora, Gili Zilberman-Schapira et al.

Cell 10.1016/j.cell.2018.08.047

[33]

10.1016/j.cell.2018.08.041

[34]

A new genomic blueprint of the human gut microbiota

Alexandre Almeida, Alex L. Mitchell, Miguel Boland et al.

Nature 10.1038/s41586-019-0965-1

[35]

10.1038/s41587-018-0009-7

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References

Details

Published: Jun 05, 2020
Vol/Issue: 56(11)
Pages: 1735-1738
License: View

Authors

E

Edward M Giles

Centre for Innate Immunity and Infectious Disease Hudson Institute for Medical Research Melbourne Victoria Australia; Department of Paediatrics Monash University Melbourne Victoria Australia

J

Jenny Couper

Discipline of Paediatrics The University of Adelaide Adelaide South Australia Australia

Cite This Article

Edward M Giles, Jenny Couper (2020). Microbiome in health and disease. Journal of Paediatrics and Child Health, 56(11), 1735-1738. https://doi.org/10.1111/jpc.14939

Microbiome in health and disease

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